Chemically activating neurons and placing mice in stimulating environments reverses alterations and restores some neural connectivity in frontotemporal dementia. If translated into humans, the findings could help develop new treatments for fighting the effects of dementia in the elderly.
Participating in exercise improved synaptic pruning in mouse models of autism. The study also found microglia dependant synaptic pruning is impaired by maternal inflammation, which has been previously connected to the development of ASD.
Researchers observe inhibitory neurons which link olfaction with cognition and memory in mice.
Researchers report altering synaptic plasticity leads to a computational switch in a hippocampal synapse which turns the presynaptic neuron turns into “detonator” mode, causing it to fire more readily.
Researchers report newborn granule cells in the dentate gyrus become less excitable after three weeks. The loss of excitability is crucial for the functioning of mature neurons.
A new study could shed light on how the cerebellum encodes information.
Researchers at Cincinnati Children’s Hospital Medical Center report that molecular disruptions in small neurons called granule cells – located in the dentate gyrus region of the brain – caused brain seizures in mice similar to those seen in human temporal lobe epilepsy.
A new study reveals how a prion-like protein that is encoded by the TIA1 gene helps to regulate fear memories. TIA1, researchers report, may be a promising new target for the treatment of PTSD.
A new study describes the epigenetic mechanisms that underlie the development of the cerebellum.