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GPCR

·December 9, 2024·3 min read

New Target for Chronic Pain Identified

Researchers have identified a natural substance, hederagenin, that blocks the NPFFR1 receptor, a protein involved in pain perception in the brain and spinal cord. NPFFR1 has long been a challenging target due to its similarities to related receptors, but advanced screening and computer modeling revealed its unique binding mode.

Featured Neuroscience

·May 11, 2021·4 min read

Researchers Use Eel-Like Protein to Control Brain

Parapinopsin, a protein found in lamprey, is being used by researchers to manipulate brain circuitry. The protein is able to switch off specific brain circuits.

Featured Neurology

·August 8, 2016·5 min read

Beneficial Role Clarified for Brain Protein Associated with Mad Cow Disease

Researchers report a protein normally associated with prion diseases may help to maintain myelin.

Image shows a woman sitting at a table and two transparent men.

Featured Psychology

·February 3, 2016·4 min read

An Alternative Treatment Target For Schizophrenia

A new study suggests that dysregulation in the way two G protein-coupled receptors talk to each other may be responsible for some symptoms of schizophrenia.

Electrophysiology Featured Neuroscience

·July 12, 2012·10 min read

Large, Medically Important Class of Proteins Starts to Yield Its Secrets

Five recent research papers shed light on elusive G protein-coupled receptors. New techniques and insights used to solve the GPCR structures are discussed.