Socially isolated individuals may have an increased risk of physical inflammation in the body. Researchers found social isolation was associated with the presence of C-reactive protein and increased levels of glycoprotein fibrinogen. The link between social isolation and physical inflammation was more common in males.
Injecting extracellular vesicles from healthy mice into mice that had an MS-like disease resulted in the development of a relapse-remitting disease and active CD8+ cells, similar to that seen in human patients with multiple sclerosis. Examining the EVs in mice and humans with MS, researchers identified they contained fibrinogen, a protein normally associated with blood clotting and wound healing. According to researchers, the EVs with fibrinogen appear to activate the CD8+ immune cells. The findings could help with the development of new treatments for RRMS.
Researchers have identified a potential new biomarker for cognitive decline associated with Alzheimer's disease. The study reports fibrinogen, a blood clotting protein, causes a series of molecular events that may trigger the destruction of connections between neurons, resulting in cognitive decline.
A new study sheds light on demylination diseases like Multiple Sclerosis. Researchers discovered a blood clotting protein can leak into the central nervous system and prevent myelin production.
Researchers report disruption of the BBB can trigger a cascade of events that result in brain damage and autoimmunity characteristic of MS.
Researchers devise a new molecular sensor which can detect multiple sclerosis at its earliest stage.