A study comparing psilocybin to the SSRI escitalopram found both drugs improved depressive symptoms similarly over six months, but psilocybin offered additional psychosocial benefits. Patients taking psilocybin reported a greater sense of meaning, psychological connectedness, and improved social functioning. These results suggest psilocybin could provide a more holistic treatment option for depression, addressing both symptoms and overall well-being. While promising, psilocybin remains experimental and is only administered in controlled environments.