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early life stress

·April 2, 2026·6 min read

Aggression Switch: Brain Path That Turns Threats into Attacks Found

Researchers have identified a neural pathway (LH to DRN) that controls physical attacks in mice without affecting threat displays. The study suggests that maladaptive aggression may be driven by an internal "aversive" state linked to early-life stress.

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·March 3, 2025·4 min read

Brain Changes From Early-Life Stress May Be Reversible

A new study reveals how prenatal infections followed by early-life stress—known as "two-hit stress"—can lead to brain dysfunction and psychiatric-like behaviors. Researchers found that affected mice showed abnormal cerebellar activity, increased microglial turnover, and impaired brain-wide connectivity.

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·July 15, 2020·4 min read

Early Life Stress Associated with Youth Onset of Depression for Some Types of Stress But Not Others

Examining the impact of eight types of early life stress on the onset of youth-onset depression, researchers found some had little impact on the development of the psychological disorder. Emotional abuse was more strongly associated with the development of major depressive disorder than other early stressors, such as poverty.

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·June 25, 2019·4 min read

Mechanisms underlying early life stress and irritable bowel syndrome discovered

Mice that experienced early life stress and later developed irritable bowel syndrome had significantly higher levels of intestinal stem cells and enterochromaffin (EC). Additionally, the mice expressed elevated secretion of serotonin as a result of the increased EC cell density.

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·December 1, 2018·7 min read

Early Life Stress Hinders Neuron Development, Causing Attention Disorders: Mouse Study

Female mice who experienced early life stress developed problems and had fewer neurons in areas of the brain responsible for regulating emotions and making sense of rules, researchers report.

Featured Neuroscience Psychology

·November 5, 2018·2 min read

Lasting Effects of Early Life Stress on Genome, Gut and Brain

Researchers report stress during fetal development and early childhood can have lasting implications for brain development, leading to increased risks of brain disorders later in life.

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·April 15, 2017·4 min read

A Crooked Bite May Indicate Early Life Stress

New research proposes asymmetry in the lower face could be a novel marker that signifies early life stress.

Featured Open Neuroscience Articles Psychology

·October 11, 2016·7 min read

Predicting With High Accuracy if Antidepressants Will Help

A new study reports researchers were able to predict with 80 percent accuracy whether antidepressants would help patients by analyzing their brain function and personal history.