A newly designed synthetic compound could act as a prototype for a novel class of drugs to treat neurological damage.
In mouse models of Alzheimer's disease, active neurons still encode memory, and a group of active neurons encodes novel environmental information. The signal of the novelty containing neurons causes a superimposition disturbing the signal of memory encoding neurons.
The NLPR3 inflammasome and the inflammatory response it triggers play a critical role in the emergence of tau pathology.
Embryonic damage caused by autoantibodies is implicated in a range of behavioral and psychological disorders, including schizophrenia, autism, and ADHD.
Using a gene vector, researchers channeled the blueprint of the human tau protein into different aged mice. After a period of twelve weeks, the tau protein spread twice as fast in older mice than the younger cohort. Findings shed light on why Alzheimer's is predominantly an age-related neurodegenerative disease.