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This shows a drawing of a head, intestines and microbes

·December 21, 2021·4 min read

Gut-Derived Metabolites That Play a Role in Neurodegeneration Identified

Researchers have identified high levels of three gut-produced toxic metabolites in plasma and cerebrospinal fluid samples of patients with multiple sclerosis.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·September 24, 2021·3 min read

Sonic Hedgehog Protein Pathway Stimulation Could Help Parkinson’s Patients

Drugs that increase signaling of Sonic Hedgehog (Shh) can help suppress the involuntary movements associated with dopamine replacement therapy for those with Parkinson's disease.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·June 7, 2021·3 min read

Molecule Critical to Functional Brain Rejuvenation Identified

TET1, a newly identified molecule appears to play a key role in myelin repair. The findings could have implications for the treatment of a range of neurodegenerative diseases, including multiple sclerosis.

Featured Neuroscience Open Neuroscience Articles Psychology

·August 13, 2019·4 min read

Glial cells are critical players in brain’s response to social stress

The behavior of oligodendrocytes plays a critical role in determining whether we tolerate or succumb to stress.

Featured Genetics Neurology Neuroscience

·July 15, 2019·5 min read

Differences in MS patients’ cerebrospinal fluid may be key to drugs that halt progression

Ceramide exposure impairs the ability for neurons to make energy by directly damaging mitochondria. Additionally, ceramides force neurons to rapidly uptake glucose in order to provide cellular energy.

This shows the differences in ceramide levels in those with a higher BMI

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·April 11, 2019·5 min read

Body mass index may play a significant role in the progression of multiple sclerosis

Obesity and a higher body mass index negatively impacts the progression of Multiple Sclerosis. Ceramides are more abundant in the blood of those who are overweight. The ceramides enter inside the nucleus of monocytes, causing proliferation. The increased number of monocytes travel back to the brain, causing more damage for those with RRMS.