Obesity and a higher body mass index negatively impacts the progression of Multiple Sclerosis. Ceramides are more abundant in the blood of those who are overweight. The ceramides enter inside the nucleus of monocytes, causing proliferation. The increased number of monocytes travel back to the brain, causing more damage for those with RRMS.
Ceramide exposure impairs the ability for neurons to make energy by directly damaging mitochondria. Additionally, ceramides force neurons to rapidly uptake glucose in order to provide cellular energy.
TET1, a newly identified molecule appears to play a key role in myelin repair. The findings could have implications for the treatment of a range of neurodegenerative diseases, including multiple sclerosis.
Drugs that increase signaling of Sonic Hedgehog (Shh) can help suppress the involuntary movements associated with dopamine replacement therapy for those with Parkinson's disease.
Researchers have identified high levels of three gut-produced toxic metabolites in plasma and cerebrospinal fluid samples of patients with multiple sclerosis.