By altering the epigenetic markers on chromosomes, researchers witnessed changed gene expression in offspring and grand-offspring. The findings reveal the occurrence of transgenerational epigenetic inheritance.
Study reports that age-related loss of the Y chromosome in men is linked to heart muscle scarring and an increased risk of heart failure. The findings may explain why men tend to die, on average, seven years younger than women.
Oxidative damage to telomeres can trigger cellular senescence. The findings could lead to the development of new therapeutics for healthy aging and to combat cancers.
Study of female fertility from age 9 to menopause reveals specific mechanisms that may affect fertility at different ages. The mechanisms depend on naturally occurring chromosome errors that vary depending on age.
UCSD researchers have developed a single cell sequencing method that can map the cellular origin of a wide variety of neurological and psychiatric disorders.