Natural resistance to capsaicin's effect in birds drove researchers to investigate a specific genetic variant that appears to be associated with pain resistance. They discovered the K710N human variant dialed down pain associated with capsaicin while enhancing the protective benefits of TRPV1. The findings could pave the way for the development of new treatments to manage pain.
Spicy food lovers may be at greater risk of dementia than those who prefer more bland foods. A 15-year study reveals those who ate more than 50 grams of chili a day had an increased risk of cognitive decline as they aged. The memory decline was more significant in those with a lower BMI.
A new study challenges the most influential textbook explanation of how the mammalian brain detects when the body is becoming too warm.