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Buck Institute

·July 1, 2025·5 min read

Clearing Brain Sugar Stores Could Protect Against Dementia

New research reveals that sugar metabolism in brain cells may be a crucial defense against Alzheimer’s and related dementias. Scientists found that neurons in both flies and human models of tauopathy accumulate excess glycogen, which disrupts cellular stress management when it can’t be broken down.

Featured Neuroscience

·December 2, 2024·6 min read

Ketone Bodies Clear Damaged Proteins in the Brain

Ketone bodies, known for their role in energy metabolism during fasting, have been shown to directly interact with damaged proteins in the brain, aiding their clearance through autophagy. Researchers discovered that the ketone body β-hydroxybutyrate alters the solubility of misfolded proteins, facilitating their removal and reducing pathological aggregation.

Featured Neuroscience

·June 18, 2024·7 min read

Keto Diet Boosts Memory in Aging

A new study reveals how a ketogenic diet, high in fat and low in carbohydrates, improves memory in aging mice. Researchers found that the diet triggers a molecular signaling pathway that enhances synapse function, leading to improved memory. This discovery could pave the way for new therapies targeting memory without the need for dietary changes.

Featured Genetics Neurology Neuroscience

·May 16, 2024·7 min read

Mitochondrial Boost Reverses Protein Clumping in Aging and Alzheimer’s

A new study in worms reveals a core set of insoluble proteins linked to both aging and Alzheimer's disease. These proteins accumulate during normal aging and are exacerbated by amyloid beta, a hallmark of Alzheimer's.

Featured Genetics Neuroscience

·January 12, 2024·6 min read

Eat Less, Live Longer: Dietary Restrictions Increase Lifespan and Improve Brain Health

Recent research reveals a significant discovery about dietary restriction and its impact on brain health and aging. They identified the OXR1 gene as crucial for extending lifespan and ensuring healthy brain aging, particularly in response to dietary restriction.

Featured Neuroscience

·December 6, 2022·5 min read

Chronological Age, Biological Age and Gender Affect the Shrinkage of Different Brain Areas

Functional brain networks and brain shrinkage are affected in different ways by age, gender, and blood immune factors.

Featured Neurology Neuroscience

·August 15, 2022·6 min read

New Role for Blood-Brain Barrier in Neuron Function and Damage

The signals that originate in the cells of the blood-brain barrier also play a direct role in controlling what happens to the neurons the barrier is protecting.

Featured Neuroscience Open Neuroscience Articles Visual Neuroscience

·June 7, 2022·6 min read

An Intriguing Connection Between Diet, Eye Health, and Lifespan

A new study of drosophila reveals a link between circadian rhythm, diet, lifespan, and eye health. Unexpectedly, researchers found processes in the fly eye that appear to drive the aging process.

Featured Genetics Neuroscience Open Neuroscience Articles

·September 8, 2021·5 min read

Aging: It’s More Complicated Than We Thought

A new study on aging reveals a surprising discovery about the connection between protein shape and mitochondrial health.

Featured Neurology Neuroscience

·March 29, 2021·4 min read

Chronic Viral Infections Can Have Lasting Effects on Human Immunity, Similar to Aging

Chronic viral infections have a profound and lasting impact on the immune system in a similar way to aging. Chronic inflammation that occurs as a result of immune system dysregulation is often seen in diseases associated with aging.

Featured Neurology

·January 23, 2018·3 min read

New Therapeutic Avenue for Parkinson’s

A new study reports researchers have identified a possible new avenue for treating Parkinson's symptoms and neuropathology. Clearing senescent astrocytes appears to help prevent sporadic versions of the disease triggered by exposure to pesticides.

Featured Neuroscience Open Neuroscience Articles

·September 5, 2017·5 min read

Ketogenic Diet Improves Lifespan and Memory in Aging Mice

Researchers report mice that were put on a ketogenic diet showed significant improvements in memory and were more likely to survive to older ages than those on different diets.

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Buck Institute

Clearing Brain Sugar Stores Could Protect Against Dementia

Ketone Bodies Clear Damaged Proteins in the Brain

Keto Diet Boosts Memory in Aging

Mitochondrial Boost Reverses Protein Clumping in Aging and Alzheimer’s

Eat Less, Live Longer: Dietary Restrictions Increase Lifespan and Improve Brain Health

Chronological Age, Biological Age and Gender Affect the Shrinkage of Different Brain Areas

New Role for Blood-Brain Barrier in Neuron Function and Damage

An Intriguing Connection Between Diet, Eye Health, and Lifespan

Aging: It’s More Complicated Than We Thought

Chronic Viral Infections Can Have Lasting Effects on Human Immunity, Similar to Aging

New Therapeutic Avenue for Parkinson’s

Ketogenic Diet Improves Lifespan and Memory in Aging Mice

Oxytocin Boosts Mother-Infant Bond in Postpartum Depression

Common Pain Medication Linked to Cognitive Decline Risk

Inverse Graphics: How Your Brain Turns 2D Into 3D

Familiar Faces and Fights: What Monkeys Like to Watch Most

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