Study identified five genes, including two novel genes, associated with Lewy Body dementia. Researchers also found the genetic profiles of patients with LBD showed higher chances of also suffering from Alzheimer's and Parkinson's disease than other age-matched control subjects.
BIN1, a gene associated with Alzheimer's disease, regulates hippocampal neural activity. Neurons with higher levels of BIN1 fired more often and were more prone to hyperexcitability. BIN1 is the first gene to be linked to hyperexcitability as a driving factor for the development of Alzheimer's disease.
Researchers provide evidence that certain species of human herpesvirus contribute to the development of Alzheimer's disease. The study reports high levels of human herpesvirus 6A and 7 were found in brain samples showing signs of Alzheimer's neuropathology. The findings offer hints of the viral mechanisms that could trigger or exacerbate AD.