Researchers found significant differences in samples from the appendix of people with Parkinson's disease, specifically in microbial composition correlating with higher levels of toxic bile acids.
Researchers report bile acids play a key role in providing positive metabolic effects after weight loss surgery. The study also suggest the intestinal microbiome participates in post surgical improvements following gastric bypass. The findings could help develop new treatments for diabetes and obesity, researchers report.
Using mouse models, researchers found bile diversion surgery reduced cocaine induced increases in dopamine release and cocaine related behaviors. Researchers believe bariatric surgery or the consumption of a synthetic bile drug may help curb cocaine addiction in humans.