Apoptosis plays a critical role in brain development as it influences the thickness of layers in the cerebral cortex, variety, and layer cell density. Alterations in how cells perform division and apoptosis lead to the development of abnormal cortical structures as seen in a variety of neurodevelopmental disorders, including autism. Read More
A nuclear fragment protein activates Xkr4 to display an "eat me" signal to phagocytes. Read More
Researchers have identified a mechanism triggered at neuron birth to intrinsically decrease apoptosis. When the genetic regulation is halted, continuous neuronal survival is disrupted, leading to a decrease in animal survival. Read More
Researchers have mapped the interaction between SARS-CoV-2 proteins and human cells, showing which proteins are being activated and deactivated by coronavirus. The findings reveal how the virus can spread through the human body. Read More
Genetically preventing apoptosis during brain growth allows 'zombie' cells to develop into functioning neurons. Read More
Early birth prompted apoptosis to begin a day early, but delaying the birth did not alter when cell death began to occur. The study suggests birth time has an important and previously unrecognized effect on brain development. Read More
TNFR1 receptors arrange themselves into clusters, joining together trimers and making oligomers that create a pro-inflammatory response observed in a variety of diseases. Read More
Increasing SIRT3 levels with a ketone rich diet may help protect GABAergic interneurons and delay the onset of Alzheimer's disease. Read More
Rather than having an equal chance of survival, cell death appears to be controlled by a mechanism that filters our the less fit cells. Read More
When a motor neuron-specific pool of heat shock protein 90 (Hps90) was inhibited, motor neuron apoptosis was triggered. Read More
A lack of oxygen as a result of preterm birth does not cause hippocampal neurons to die but does impair hippocampal development. Hypoxia causes hippocampal cells to fail to mature normally, causing a reduction in long-term potentiation and impaired learning. Read More
A new study into human and plant cell apoptosis could provide new avenues for the development of treatments for neurodegenerative diseases, and help develop disease-resistant plants. Read More