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ApoE2

·September 21, 2022·6 min read

Common Alzheimer’s Gene Variant Linked to COVID Mortality

Mice with the Alzheimer's disease-associated APOE4 and the APOE2 genes were more likely to die from COVID-19 than those with the APOE3 gene. Those with APOE4 and APOE2 genes had more virus replication in the lungs, higher inflammation, and increased tissue damage following coronavirus infection.

This is an illustration of neurons, amyloid plaques and tau

Featured Neurology Neuroscience

·October 29, 2021·4 min read

Key Alzheimer’s Feature Eliminated in Animal Model

Inhibiting the NHE6 gene abolished the formation of amyloid-beta plaques in mouse models of Alzheimer's disease.

This shows a plastinated alzheimer's brain.

Featured Genetics Neurology

·September 9, 2015·5 min read

Researchers Discover a Potential Protective Shield From Alzheimer’s Disease

ApoE2 appears to have neuroprotective properties and could be key in the fight against Alzheimer's disease, according to a new study.

The image is a diagram comparing the difference between neuron damage and associated damage in alzheimer's disease with normal neurons.

Featured Neurology

·November 20, 2013·5 min read

Study Reveals How Variant Forms of APOE Protein Impact Risk of Alzheimer’s Disease

A new study reports even low levels of APOE4 can increase beta-amyloid plaques in the brain and neuronal damage in mouse models of Alzheimer's disease. However, introducing APOE2 can reduce amyloid deposits and other associated damage.