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ApoE

Featured Genetics Neurology Neuroscience

·July 25, 2026·8 min read

Alzheimer Genetic Risk Scores Do Not Explain SuperAging

A new study demonstrates that SuperAgers cannot be distinguished from cognitively average peers by APOE status or polygenic risk scores.

Featured Genetics Neuroscience

·September 21, 2022·6 min read

Common Alzheimer’s Gene Variant Linked to COVID Mortality

Mice with the Alzheimer's disease-associated APOE4 and the APOE2 genes were more likely to die from COVID-19 than those with the APOE3 gene. Those with APOE4 and APOE2 genes had more virus replication in the lungs, higher inflammation, and increased tissue damage following coronavirus infection.

Featured Genetics Neurology Neuroscience

·February 2, 2022·4 min read

New Non-Mutated Protein Linked to Dementia

APOE proteins were enhanced in the brains of patients with dementia, even when they did not carry the Alzheimer's associated gene.

Featured Neurology Neuroscience

·August 14, 2021·5 min read

Brain Cholesterol Regulates Alzheimer’s Plaques

A new advanced imaging technique shows how cholesterol regulates the production of Alzheimer's associated amyloid beta proteins in astrocytes.

Featured Genetics Neurology Neuroscience

·May 6, 2021·6 min read

Why Do Some Neurons Degenerate and Die in Alzheimer’s Disease, but Not Others?

Study reveals the molecular clues as to why some neurons are susceptible to death in Alzheimer's disease while others aren't.

This shows a doctor looking at a spinal cord x ray

Featured Neurology Neuroscience

·February 26, 2021·5 min read

The Impact of Patient Sex on Treatment Strategies for Spinal Cord Injuries

Both the ApoE genotype and the sex of the mouse impacted the manner in which the animals with spinal cord injury responded to hypoxia treatment. Females with the ApoE e4 gene had a negative response to intermittent hypoxia.

This shows an older man holding his head in pain

Featured Genetics Neurology Neuroscience Pain

·February 24, 2021·4 min read

Pain Perception Could Help Diagnose Alzheimer’s Before Symptoms Occur

Altered pain perception could be a new biomarker to assess late-onset Alzheimer's risk in cognitively healthy individuals with the AopE4 gene before symptoms occur.

This shows two brain tissue samples, one with amyloid and another after treatment to remove the amyloid

Featured Genetics Neurology Neuroscience

·February 21, 2021·6 min read

Protein Linked to Alzheimer’s and Strokes Cleared From Brain Blood Vessels

An antibody called HAE-4 targets APOE and removes Alzheimer's related amyloid plaques in mouse models. The antibody improves blood vessel function in the brain without raising the risk of brain bleeds.

Featured Genetics Neurology Open Neuroscience Articles

·September 15, 2020·5 min read

Risk Gene for Alzheimer’s Has Early Effects on the Brain

Young adults with the Alzheimer's associated ApoE gene had differences in brain activity when presented with memory tasks.

Featured Genetics Neurology Neuroscience

·April 13, 2020·7 min read

Gene variant staves off Alzheimer’s in some people

Carriers of one copy of the longevity associated klotho gene reduces Alzheimer's risks by 30% for those with genetic risk factors for the neurodegenerative disease.

Featured Neurology Neuroscience

·March 5, 2020·3 min read

Exercise may slow brain aging by 4 years

Frequent exercise, such as walking, swimming, and dancing, was associated with less brain shrinkage in older adults. The effect of exercise in older people was equal to four fewer years of brain aging.