Both the ApoE genotype and the sex of the mouse impacted the manner in which the animals with spinal cord injury responded to hypoxia treatment. Females with the ApoE e4 gene had a negative response to intermittent hypoxia.
An antibody called HAE-4 targets APOE and removes Alzheimer's related amyloid plaques in mouse models. The antibody improves blood vessel function in the brain without raising the risk of brain bleeds.
Progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS), two atypical parkinsonian syndromes, may be twice as common as previously believed, researchers report.
People with a genetic predisposition for Alzheimer's disease may exhibit changes in memory up-to four decades before the typical age of dementia onset.