Neurturin, a muscle-produced protein, improves muscular metabolism, motor coordination, and exercise performance in mouse models. The discovery could have implications for treating ALS and other disorders associated with neurological disorders that affect muscles.
Cryogenic-electron microscopy allowed researchers to determine the basic building blocks of prion proteins, including the placements of their amino acids.
Riluzole, a drug commonly prescribed to slow the progression of ALS, appears to slow brain metabolic decline and improve cognitive performance in those with mild Alzheimer's disease.
Cedars-Sinai has been awarded $11.99 million by California's stem cell agency to launch a clinical trial testing a potential gene and stem cell therapy for amyotrophic lateral sclerosis (ALS).
Researchers found an increased inflammatory signal in patients with the C90rf72 subtype of ALS. The increased inflammatory biomarkers could be found in peripheral serum tests.
Researchers have identified a causal link between strenuous exercise and ALS in people with genetic risk factors for the neurodegenerative disease. The study reports intense physical exercise contributes to motor neuron injury in those susceptible to ALS.
Inhibitory neurons in the spinal cord lose their connections to motor neurons in mouse models of ALS. While no connection between this deterioration to the development of ALS has been made, researchers say the loss of inhibitory signals could explain why motor neurons die in those with ALS.
A new brain-computer interface could help thousands of people with neurodegenerative disorders and spinal cord injuries the ability to regain communication skills. The BCI, in combination with a machine learning algorithm, can generate words on a screen, based on a person thinking about writing the word.