NU-9, a novel, non-toxic compound, targets upper motor neurons and reverses damage associated with ALS within 60 days of treatment. Read More
Some neurons have the ability to detect and compensate for neighboring neurons, while others do not. The findings shed new light on synaptic plasticity. Read More
Ezogabine, an antiepileptic drug, reduces the excitability of cortical and spinal motor neurons associated with ALS. Read More
A novel method detected conformational changes to the TDP-43 protein in cerebral spinal fluid associated with ALS. Read More
Researchers find a previously unknown connection between ALS, FTD, and the Huntington's disease associated gene, huntingtin. Read More
Findings have implications for a better understanding of how brain plasticity occurs. Read More
An examination of brainstems from children and young adults constantly exposed to air pollution reveals markers of Alzheimer's disease, Parkinson's disease, and motor neuron disease. Findings suggest air pollution poses risks of serious neurological damage from an early age. Read More
A defective protein quality control system leads to motor neuron death associated with disorders like ALS. Read More
c9ASO, an investigational ASO drug, targets the TDP-43 protein, reducing its buildup and decreasing neurological decline associated with ALS and FTD. Read More
Ebselen, a Selenium-based drug molecule, and several other novel compounds can change the characteristics of SOD1. The findings could help with the development of new therapeutics for ALS. Read More
A preclinical study reports Schwann cells assist injured axons by releasing protective sugars. The findings have positive implications for the treatment of neurodegenerative diseases like ALS. Read More
Study reveals why some people with ALS are prone to developing autoimmune diseases. A genetic mutation that decreases the expression of C9orf72 causes the stimulation of interferon genes (STING) protein to become hyperactive. The hyperactivity leads to increased production of interferons. This can lead to systemic inflammation and the development of autoimmune diseases. Read More
