Human-on-a-chip technology could provide a more valuable clinical-based model for ALS. Read More
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Researchers have identified how specific genetic mutations cause ALS. The pathway, they believe, may also be responsible for the development of frontotemporal dementia. Read More
Researchers have identified a new, early biomarker for amyotrophic lateral sclerosis (ALS) on the teeth of children. Patients who were diagnosed with ALS in adulthood showed signs of dysregulation uptake of a mixture of essential elements, including zinc, copper, lead, and tin, on their teeth. The study is the first to show clear signatures at birth and within the first decade of life for ALS. Read More
Study reveals a new gut-brain connection in amyotrophic lateral sclerosis (ALS). The gut microbiome could influence the severity of the neurodegenerative disease. Altering the bacteria in the gut may prevent or improve symptoms of ALS. Read More
Study reveals a self-corrective mechanism within synapses that is activated by neurodegeneration and slows disease progression in animal models of ALS. Read More
Increasing the activity of interneurons in later 5 of the primary motor cortex in mouse models of ALS effectively slowed the onset of the disease. Read More
A new method called Tox-seq found only one sub-group of microglia caused oxidative stress. The gene expression signatures of this sub-group from a mouse model matched patterns observed in cells suspected of causing damage in progressive multiple sclerosis patients. The pattern of gene expression associated with oxidative stress in mouse cells included genes involved in coagulation. Read More
The TBK1 gene regulates the disease progression of ALS in mouse models of the neurodegenerative disease. Loss of the TBK1 gene in motor neurons increases SOD1 aggregation and accelerates the onset of the disease. Read More
Study reports repeats in genes associated with Fragile X syndrome normally regulate how and when proteins are made in neurons. Read More
Study reports protein aggregates within cells are cleared out by the endocytosis process. The findings could help with the development of new treatments for ALS. Read More
Researchers have developed a new method for delivering neural precursor cells into rat models of spinal cord injury. The method is safe, effective, and reduces the likelihood of further spinal trauma while delivering larger doses of reparative stem cells. The new approach could also be used for the treatment of ALS and multiple sclerosis. Read More
Researchers have identified a set of drug-like compounds, including a common ingredient in throat lozenges, that can help protect mitochondria from the stresses associated with neurodegenerative diseases. Read More
