Inhibitory neurons in the spinal cord lose their connections to motor neurons in mouse models of ALS. While no connection between this deterioration to the development of ALS has been made, researchers say the loss of inhibitory signals could explain why motor neurons die in those with ALS.
SPTLC1, a gene linked to the fat production system, has been implicated in a newly identified ALS-like disease in children.
A new brain-computer interface could help thousands of people with neurodegenerative disorders and spinal cord injuries the ability to regain communication skills. The BCI, in combination with a machine learning algorithm, can generate words on a screen, based on a person thinking about writing the word.
Using single nucleus RNA sequencing, researchers have mapped 21 subtypes of motor neurons in the spinal cords of mice.
The LSM12-EPAC1 pathway is an important suppressor of the NCT-related pathologies associated with ALS and FTD.
Separating vascular cell data based on sex helps researchers make new discoveries about why males and females are affected by neurodegenerative diseases differently. Findings point to differences in the blood-brain barrier between males and females.
NU-9, a novel, non-toxic compound, targets upper motor neurons and reverses damage associated with ALS within 60 days of treatment.
Some neurons have the ability to detect and compensate for neighboring neurons, while others do not. The findings shed new light on synaptic plasticity.
Ezogabine, an antiepileptic drug, reduces the excitability of cortical and spinal motor neurons associated with ALS.
A novel method detected conformational changes to the TDP-43 protein in cerebral spinal fluid associated with ALS.
Researchers find a previously unknown connection between ALS, FTD, and the Huntington's disease associated gene, huntingtin.
Findings have implications for a better understanding of how brain plasticity occurs.