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2-AG

·May 20, 2025·4 min read

Body’s Own Cannabinoids May Help Control Trauma-Linked Fear

A new study reveals that a natural cannabinoid in the body, 2-AG, plays a crucial role in regulating fear responses, particularly in individuals with PTSD and anxiety. Researchers found that lower levels of 2-AG in both mice and humans were linked to exaggerated or overgeneralized fear reactions to non-threatening stimuli. This suggests that 2-AG helps the brain distinguish real threats from harmless cues, acting as a natural filter for fear.

Featured Neurology Neuroscience

·August 4, 2021·6 min read

Marijuana-Like Brain Substance Calms Seizures but Increases After-Effects

The release of 2-AG, a natural endocannabinoid that is suggested to be the brain's equivalent to THC, dampens down seizure activity but increases post-seizure oxygen deprivation in the brain.

This is a drawing of a head made up of cannabis leaves

Featured Neuroscience Psychology

·January 13, 2020·3 min read

Study sheds light on link between cannabis, anxiety and stress

A naturally occurring molecule produced by the brain activates endocannabinoid receptors, protecting against stress by reducing anxiety-producing connections between the amygdala and the prefrontal cortex. The findings may help explain why people turn to marijuana when they feel anxious or stressed.

Autism Featured Neuroscience

·February 9, 2018·4 min read

Study Helps Map Signaling System in Brain Linked to ASD

Vanderbilt researchers have mapped a signaling system in the brain that appears to be linked to autism.

Image shows a coronal brain slices from DAGLαf/f mouse.

Featured Neuroscience Open Neuroscience Articles Psychology

·March 29, 2017·4 min read

Natural Chemical Helps Brain Adapt to Stress

Researchers report deficiencies of natural cannabinoids could result in a predisposition for developing depression and PTSD. Boosting the system could help in treating stress related disorders.