Moderate Preterm Birth Linked to Neurodevelopmental Risks

Summary: A new study reveals that moderate preterm birth (32-38 weeks) is linked to an increased risk of developmental disorders. Analyzing over 75 studies involving more than eight million children, researchers found heightened risks of disorders such as cerebral palsy, cognitive impairment, and language delay in children born moderately preterm.

While the risk for each child is small, the population-level impact is significant, given that around 7% of UK babies are born moderately preterm each year. The study highlights the need for better understanding and support for these children, emphasizing the role of healthcare professionals and educators in early intervention and tailored support.

Key Facts:

  1. Children born moderately preterm face increased risks of developmental disorders, including language delay, low educational attainment, and cerebral palsy.
  2. The study reviewed data from over eight million children and found that risks decrease with each additional week of gestation, but even “early term” births (37-38 weeks) carry increased risks.
  3. The study calls for improved communication between schools, parents, and health professionals, and better support for teachers in managing children born preterm.

Source: University of York

While many of the increased risks are small, because around seven percent of babies in the UK are born moderately preterm each year, they could have significant consequences at population level, the authors of the National Institute of Health and Care Research (NIHR) funded study say. 

For the study, researchers at the Universities of York, Leeds and Leicester examined data from more than 75 studies from around the world, which involved a total of over eight million children. 

This shows a baby.
While the risk of cerebral palsy is relatively low for all children, the results of the study suggest it is 14 times higher for infants born at 32 to 33 weeks compared with children born at full term. Credit: Neuroscience News

Compared with children born at full term, the study identified an increased risk of most developmental disorders. Whilst risks decreased with each week of gestation, there was still evidence of a small increase in risk of several developmental disorders such as cerebral palsy, developmental delay, and cognitive impairment, even when children were  born “early term”, between 37-38 weeks.

One of the most common disorders was language delay which affected 222 per 1000 children born between 32-36 weeks, compared with 47 per 1000 for full term children. Many children face low educational attainment during the primary school years, affecting 300 per 1000 children born moderately preterm, compared to 160 per 1000 children born at full term.

While the risk of cerebral palsy is relatively low for all children, the results of the study suggest it is 14 times higher for infants born at 32 to 33 weeks compared with children born at full term. 

The review also found that difficulties faced by children born at 32 to 38 weeks persist through childhood, with evidence of increased risk and prevalence of cognitive impairment and low educational achievement persisting into the high school years. 

Lead author of the study, Dr Katherine Pettinger from the Department of Health Sciences at the University of York, said: “It is important to remember that whilst our study shows an increase in risk for children born moderately early relative to their peers born at full term, many children will not experience any developmental problems.

“The reasons behind our findings are not yet clear, but babies born just a few weeks early have different brain maturation to full term children, and it is possible that birth between 32 and 38 weeks’ gestation may disrupt evolution of neural connections, potentially contributing to developmental disorder. 

“Many babies that are born moderately preterm are delivered early for very good reasons, for example when the mother has a health condition such as preeclampsia. However, understanding the long-term implications of birth before full term may influence obstetric decision making in some cases.

“It is also vital that all healthcare professionals, and particularly pediatricians, are well informed of the potential consequences of preterm birth so that they can give evidence-based information to families and so opportunities for early intervention are not missed.”

According to current guidelines from the National Institute for Health and Care Excellence (NICE) children should be monitored up until the age of two if they were born before the age of 30 weeks.

The researchers do not recommend that all children born between 32 and 38 weeks’ gestation should also receive multiple routine health appointments as many will not show any signs of developmental disorders and this would place significant strain on NHS services. 

However, the researchers are calling for more communication between schools, parents and health professionals and better support for teachers. 

Dr Pettinger added: “The data tells us the effects of being just a few weeks early are still there at primary school age. It therefore makes sense for teachers to be informed if they have students who are born preterm and early term and receive training on how to support them.

“Further research is now needed to look at large scale population studies to explore how incidents of developmental disorders relate to gestational age and see if the patterns we observed in the present study are replicated.

“We also want to look at whether children are commonly affected by more than one disorder, as understanding which conditions are likely to co-occur can help to produce more tailored interventions for children.”

About this neurodevelopment research news

Author: Shelley Hughes
Source: University of York
Contact: Shelley Hughes – University of York
Image: The image is credited to Neuroscience News

Original Research: Open access.
Risk of Developmental Disorders in Children Born at 32 to 38 Weeks’ Gestation: A Meta-Analysis” by Katherine Pettinger et al. Pediatrics


Risk of Developmental Disorders in Children Born at 32 to 38 Weeks’ Gestation: A Meta-Analysis


Very preterm birth (<32 weeks) is associated with increased risk of developmental disorders. Emerging evidence suggests children born 32 to 38 weeks might also be at risk.


To determine the relative risk and prevalence of being diagnosed with, or screening positive for, developmental disorders in children born moderately preterm, late preterm, and early term compared with term (≥37 weeks) or full term (39–40/41 weeks).


Medline, Embase, Psychinfo, Cumulative Index of Nursing, and Allied Health Literature.


Reported ≥1 developmental disorder, provided estimates for children born 32 to 38 weeks.


A single reviewer extracted data; a 20% sample was second checked. Data were pooled using random-effects meta-analyses.


Seventy six studies were included. Compared with term born children, there was increased risk of most developmental disorders, particularly in the moderately preterm group, but also in late preterm and early term groups: the relative risk of cerebral palsy was, for 32 to 33 weeks: 14.1 (95% confidence intervals [CI]: 12.3–16.0), 34 to 36 weeks: 3.52 (95% CI: 3.16–3.92) and 37 to 38 weeks: 1.44 (95% CI: 1.32–1.58).


Studies assessed children at different ages using varied criteria. The majority were from economically developed countries. All were published in English. Data were variably sparse; subgroup comparisons were sometimes based on single studies.


Children born moderately preterm are at increased risk of being diagnosed with or screening positive for developmental disorders compared with term born children. This association is also demonstrated in late preterm and early term groups but effect sizes are smaller.

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