Summary: Researchers report imagining a threat can help people conquer their fears of the threat.Source: Mount Sinai Hospital.Imagining a threat can help you conquer your fear of it, according to research conducted at the Icahn School of Medicine at Mount Sinai and published November 21 in the journal Neuron. The study has strong implications for the treatment of anxiety and fear-related disorders.The research focused on the difference between how fear is learned and unlearned. People quickly learn to fear a threatening or unpleasant experience, and the fear will recur when cues, like sights or sounds, associated with the bad experience are sensed. This can negatively impact quality of life and underlie emotional disorders like post-traumatic stress disorder, phobias, and anxiety.One of the most effective ways to remove this fear is to experience the threatening cues without then having the bad experience, something known as “threat extinction” or “extinction learning.” It is the most prescribed treatment for fear-related disorders.But this type of therapy is impractical in some cases because the cues associated with a traumatic event may be difficult or unethical to reconstruct (e.g., a war zone) or because the intensity of re-exposure is overwhelming for the patient. In such cases, imagination, an internal simulation of real-life events, is a common treatment tool. But despite imagination’s longstanding recognition in the clinic, it has received little attention from the neuroscientific learning community and, therefore, the neural processes through which imagination affects behavior are unclear.To test the effectiveness of imagination in extinction learning and its neural mechanisms, Mount Sinai researchers exposed 68 study participants to auditory threat conditioning, which involved exposing them to two different sounds, one of which was paired with an uncomfortable electric shock. Next, the participants were randomized into three groups. The first group performed “imagined extinction”: that is, they were directed to “play” the conditioned tones “in their head” to the best of their ability. The second underwent “real extinction,” which consisted of actual exposures to the conditioned auditory stimuli. The third underwent no extinction; instead, they were directed to imagine two neutral sounds from nature (“birds singing” and “rain falling”) as a control for the general effects of imagination on arousal. The threat memory was then reinstated in all participants through four unsignaled shocks, after which all participants were then re-exposed to the conditioned auditory stimuli. Functional MRI images were collected for each phase and skin conductance responses were recorded continuously.“We found that imagined extinction and real extinction were equally effective in the reduction of threat-related neural and physiological responses elicited upon re-exposure to real-world threatening cues,” says Daniela Schiller, PhD, Professor of Neuroscience and Psychiatry at the Icahn School of Medicine at Mount Sinai and senior author of the paper. “More specifically, neuroimaging results indicated that imagined extinction, like standard extinction, activated a network of threat suppression involving the ventromedial prefrontal cortex as a central hub.”One of the most effective ways to remove this fear is to experience the threatening cues without then having the bad experience, something known as “threat extinction” or “extinction learning.” It is the most prescribed treatment for fear-related disorders. NeuroscienceNews.com image is in the public domain.The ventromedial prefrontal cortex is a key brain region involved in the ability to extinguish learned threat responses. It is often impaired in anxiety disorders. The current study shows that imagining threat-eliciting cues subjugates the same neural mechanisms as actual threat cues, achieving the same ability to inhibit and reduce responses to the threat in safe situations.Researchers found that the effectiveness of imagined extinction corresponded to the strength of primary auditory cortex activation, indicating that imagining a sound activates the same neural circuits involved in actual hearing. By contrast, the neural network serving the non-specific imagination was not sufficient to prevent the expression of neural and behavioral threat-related response when confronting the real-life threatening stimuli.“Our data indicate that an internal simulation of a real-world experience can alter the way one responds to that situation in the future,” says Dr. Schiller. “These novel findings bridge a long-standing gap between clinical practice and cognitive neuroscience by validating the effectiveness of imagination-based therapies targeting anxiety disorders and extending our knowledge of how mental actions can influence basic neural circuits.”[divider]About this neuroscience research article[/divider]Funding: This study was funded in part by The National Institute on Drug Abuse.Source: Elizabeth Dowling – Mount Sinai Hospital Publisher: Organized by NeuroscienceNews.com. Image Source: NeuroscienceNews.com image is in the public domain. Original Research: Open access research for “Attenuating Neural Threat Expression with Imagination” by Marianne Cumella Reddan, Tor Dessart Wager, and Daniela Schiller in Neuron. Published November 21 2018. doi:10.1016/j.neuron.2018.10.047See alsoFeaturedNeuroscienceNeuroscience Videos·April 10, 2020COVID-19: Aerosolized particles carrying virus stay in the air longer than previously thought[divider]Cite This NeuroscienceNews.com Article[/divider][cbtabs][cbtab title=”MLA”]Mount Sinai Hospital”Imagination Really Can Set You Free From Fear.” NeuroscienceNews. NeuroscienceNews, 21 November 2018. <https://neurosciencenews.com/imagination-fear-10240/>.[/cbtab][cbtab title=”APA”]Mount Sinai Hospital(2018, November 21). Imagination Really Can Set You Free From Fear. NeuroscienceNews. Retrieved November 21, 2018 from https://neurosciencenews.com/imagination-fear-10240/[/cbtab][cbtab title=”Chicago”]Mount Sinai Hospital”Imagination Really Can Set You Free From Fear.” https://neurosciencenews.com/imagination-fear-10240/ (accessed November 21, 2018).[/cbtab][/cbtabs]AbstractAttenuating Neural Threat Expression with ImaginationImagination is an internal simulation of real-life events and a common treatment tool for anxiety disorders; however, the neural processes by which imagination exerts behavioral control are unclear. This investigation tests whether and how imagined exposures to a threatening stimulus, conditioned in the real world, influence neural and physiological manifestations of threat. We found that imagined and real extinction are equally effective in the reduction of threat-related neural patterns and physiological responses elicited upon re-exposure to real-world threatening cues. Network connectivity during the extinction phase showed that imagined, like real, extinction engaged the ventromedial prefrontal cortex (vmPFC) as a central hub. vmPFC, primary auditory cortex, and amygdala activation during imagined and real extinction were predictive of individual differences in extinction success. The nucleus accumbens, however, predicted extinction success in the imagined extinction group alone. We conclude that deliberate imagination can attenuate reactions to threat through perceptual and associative learning mechanisms.[divider]Feel free to share this Neuroscience News.[/divider]Join our Newsletter I agree to have my personal information transferred to AWeber for Neuroscience Newsletter ( more information )Sign up to receive the latest neuroscience headlines and summaries sent to your email daily from NeuroscienceNews.comWe hate spam and only use your email to contact you about newsletters. We do not sell email addresses. 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