Summary: Researchers combine machine learning, EEG, and new functional imaging technology to dynamically map a neural signal’s source and underlying brain networks. Source: Carnegie Mellon University Marking a major milestone on the path to meeting the objectives of the NIH BRAIN initiative, research by Carnegie Mellon’s Biomedical Engineering Department Head Bin He advances high-density electroencephalography (EEG) as the future paradigm for dynamic functional neuroimaging. The NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) Initiative motivates researchers to “produce a revolutionary new dynamic picture of the brain that, for the first time, shows how individual cells and complex neural circuits interact in both time and space.” An ideal technique for functional human brain imaging–one of the initiative’s top priorities–would depict brain activity with high temporal resolution, high spatial resolution, and wide spatial coverage. Carnegie Mellon’s He has made a major leap forward for the field of functional neuroimaging. An NIH-funded study lasting several years and examining dozens of patients with epilepsy has produced a novel source imaging technology that uses high-density EEG recordings to map underlying brain networks. Published in Nature Communications, this research is a big step towards establishing the ability to dynamically image human brain function and dysfunction. This could provide important insight into both where and how underlying information-processing occurs. EEG has long been one of the most effective functional methods available for human brain mapping. It takes readings in a matter of milliseconds, however the technology still struggles with determining the spatial extent of activity within the brain. The approach proposed by He and his team can accurately estimate for the first time the size and scope of active areas within the brain using high-density EEG, as well as interactions between regions that are functionally related. Their findings were validated using clinical recordings made at the Mayo Clinic, analyzing a total of 1,027 EEG spikes and 86 seizures recorded from 36 patients. The team’s method, termed the fast spatio-temporal iteratively reweighted edge sparsity (FAST-IRES) technique, uses machine learning to objectively estimate signal sources and activity as they vary over time. Unlike prior imaging techniques, it needs no ad hoc algorithm or human intervention for determining source extent and requires only minimal, intuitive input from physicians. FAST-IRES could have a major impact on the research and treatment of various neurological and mental disorders like Alzheimer’s, Parkinson’s, stroke, chronic pain, and even depression. However, this method is uniquely and most immediately impactful for those suffering from drug-resistant epilepsy. Around one percent of the global population suffers from epilepsy, and roughly one-third of cases are drug-resistant, requiring surgical intervention. Yet until now, no current non-invasive imaging modality has the spatial specificity to accurately determine the epileptogenic zone (EZ), which represents the minimum amount of tissue that must be removed to halt seizures. “By analyzing epilepsy networks with our proposed FAST-IRES framework, we have demonstrated that the EZ can be determined objectively and noninvasively with high precision from scalp high density EEG recordings,” wrote He and his co-authors. There findings were validated against readings from conventional invasive intracranial recordings and surgical outcomes from each patient, proving FAST-IRES’ effectiveness. The study also marks one of the first times high-density EEG has been used to study epileptic seizures. The more powerful imaging technology, packing more than double the electrodes generally used in a clinical setting, is now available to patients treated at the Mayo Clinic. He believes that within the next five years, the FAST-IRES methodology will begin to impact the way we understand a number of neurological disorders. Signals sources are measured with high-density EEG and their extent is simulated and estimated using machine learning. Results are compared with clinical findings. Image is credited to College of Engineering. “This work demonstrates that EEG source imaging may become the non-invasive high-spatial, high-temporal resolution paradigm for human brain imaging technology, an important goal of the BRAIN Initiative.” said He, who served as a member of the NIH BRAIN Multi-Council Working Group from 2015-2019. He’s research may be life-changing for those suffering from epilepsy and could benefit researchers and physicians across the field of neurology, neurosurgery, and human neuroscience. This work brings the NIH and the scientific community one step closer to achieving a revolutionary new dynamic picture of the brain. The work is a multi-year collaboration with Dr. Gregory Worrell’s team at Mayo Clinic, Rochester. Other collaborators on the paper included first author Abbas Sohrabpour, a BME postdoctoral associate; co-authors Zhengxiang Cai and Shuai Ye, BME Ph.D. students in He’s lab; and clinical co-authors Gregory Worrell and Benjamin Brinkmann of the Mayo Clinic. Funding: This work was supported in part by the National Institute of Neurological Disorders and Stroke, National Institute of Biomedical Imaging and Bioengineering, National Institute of Mental Health, and National Center for Complementary and Integrative Health.See alsoFeaturedNeuroscience·April 6, 2020Anti-clotting drug could reduce ARDS deaths as a result of COVID-19 About this neuroscience research article Source: Carnegie Mellon University Media Contacts: Dan Carroll – Carnegie Mellon University Image Source: The image is credited to College of Engineering. Original Research: Open access “Noninvasive electromagnetic source imaging of spatiotemporally distributed epileptogenic brain sources”. by Abbas Sohrabpour, Zhengxiang Cai, Shuai Ye, Benjamin Brinkmann, Gregory Worrell & Bin He. Nature Communications doi:10.1038/s41467-020-15781-0 Abstract Noninvasive electromagnetic source imaging of spatiotemporally distributed epileptogenic brain sources Brain networks are spatiotemporal phenomena that dynamically vary over time. Functional imaging approaches strive to noninvasively estimate these underlying processes. Here, we propose a novel source imaging approach that uses high-density EEG recordings to map brain networks. This approach objectively addresses the long-standing limitations of conventional source imaging techniques, namely, difficulty in objectively estimating the spatial extent, as well as the temporal evolution of underlying brain sources. We validate our approach by directly comparing source imaging results with the intracranial EEG (iEEG) findings and surgical resection outcomes in a cohort of 36 patients with focal epilepsy. To this end, we analyzed a total of 1,027 spikes and 86 seizures. We demonstrate the capability of our approach in imaging both the location and spatial extent of brain networks from noninvasive electrophysiological measurements, specifically for ictal and interictal brain networks. Our approach is a powerful tool for noninvasively investigating large-scale dynamic brain networks. Feel Free To Share This Neurotech News. Join our Newsletter I agree to have my personal information transferred to AWeber for Neuroscience Newsletter ( more information ) Sign up to receive the latest neuroscience headlines and summaries sent to your email daily from NeuroscienceNews.comWe hate spam and only use your email to contact you about newsletters. We do not sell email addresses. You can cancel your subscription any time.