Academic Education Can Positively Affect Aging of the Brain

Summary: Older adults with an academic background showed lower increases of signs of brain degeneration than those who were less educated, a new study reports.

Source: University of Zurich

The benefits of good education and lifelong learning extend into old age. The initial findings of a long-term study show that certain degenerative processes are reduced in the brains of academics. Their brains are better able to compensate for age-related cognitive and neural limitations.

A good education is an excellent way to embark on a successful career and develop your personality. But can education also have a positive effect on our brains as we get older? A team of researchers under the University Research Priority Program “Dynamics of Healthy Aging” led by Lutz Jäncke, professor of neuropsychology at the University of Zurich, has now explored this question in a long-term study.

The researchers followed more than 200 senior citizens for over seven years. The study participants are not affected by dementia, have average to above-average intelligence and lead highly active social lives. They were examined neuroanatomically as well as neuropsychologically using magnetic resonance imaging at regular intervals.

Based on complex statistical analyses, the researchers were able to show that academic education had a positive effect on age-related brain degeneration.

White spots and black holes

In her Ph.D. thesis, first author Isabel Hotz used novel automatic methods among others to study so-called lacunes and white matter hyperintensities. These degenerative processes showed up as “black holes” and “white spots” on the digital images.

The reasons for this are not yet known and may have to do with small, unnoticed cerebral infarcts, reduced blood flow or loss of nerve pathways or neurons. This can limit a person’s cognitive performance, in particular when degeneration affects key regions of the brain.

This shows a man standing at a blackboard covered in math equations
The findings revealed that over the course of seven years, senior citizens with an academic background showed a significantly lower increase in these typical signs of brain degeneration. Image is in the public domain

The findings revealed that over the course of seven years, senior citizens with an academic background showed a significantly lower increase in these typical signs of brain degeneration. “In addition, academics also processed information faster and more accurately—for example, when matching letters, numbers of patterns. The decline in their mental processing performance was lower overall,” summarizes Hotz.

Tapping into reserves

The findings add to initial findings of other research groups, who have found that education has a positive effect on brain aging. Previous studies also suggest that mental processing speed depends on the integrity of neural networks in the brain. If these networks are affected, mental processing speed decreases.

Even though no causal link between education and reduced natural brain degeneration has so far been found, the following at least seems likely: “We suspect that a high level of education leads to an increase in neural and cognitive networks over the course of people’s lives, and that they build up reserves, so to speak. In old age, their brains are then better able to compensate any impairments that occur,” says neuropsychologist Lutz Jäncke.

It is also possible that brains that are active well into old age are less susceptible to degeneration processes, adds the neuropsychologist, though this would have to be verified in the further course of the ongoing long-term study.

About this education and brain aging research news

Author: Press Office
Source: University of Zurich
Contact: Press Office – University of Zurich
Image: The image is in the public domain

Original Research: Open access.
Associations of subclinical cerebral small vessel disease and processing speed in non-demented subjects: A 7-year study” by Hotz, I. et al. NeuroImage: Clinical


Associations of subclinical cerebral small vessel disease and processing speed in non-demented subjects: A 7-year study

Markers of cerebral small vessel disease (CSVD) have previously been associated with age-related cognitive decline. Using longitudinal data of cognitively healthy, older adults (N = 216, mean age at baseline = 70.9 years), we investigated baseline status and change in white matter hyperintensities (WMH) (total, periventricular, deep), normal appearing white matter (NAWM), brain parenchyma volume (BPV) and processing speed over seven years as well as the impact of different covariates by applying latent growth curve (LGC) models. Generally, we revealed a complex pattern of associations between the different CSVD markers.

More specifically, we observed that changes of deep WMH (dWMH), as compared to periventricular WMH (pWMH), were more strongly related to the changes of other CSVD markers and also to baseline processing speed performance. Further, the number of lacunes rather than their volume reflected the severity of CSVD. With respect to the studied covariates, we revealed that higher education had a protective effect on subsequent total WMH, pWMH, lacunar number, NAWM volume, and processing speed performance.

The indication of antihypertensive drugs was associated with lower lacunar number and volume at baseline and the indication of antihypercholesterolemic drugs came along with higher processing speed performance at baseline. In summary, our results confirm previous findings, and extend them by providing information on true within-person changes, relationships between the different CSVD markers and brain-behavior associations.

The moderate to strong associations between changes of the different CSVD markers indicate a common pathological relationship and, thus, support multidimensional treatment strategies.

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