A Gentle Method For Unlocking the Mysteries of the Deep Brain

Summary: Researchers report EEG technology has the ability to study activity of areas deep inside the brain, such as the thalamus and nucleus accumbens. The findings will help shed new light on disorders that affect these brain regions, such as Parkinson’s disease and OCD.

Source: University of Geneva.

The subcortical areas of the brain, situated in its deepest reaches, remain a mystery. Scientists are aware of the critical role they play in motor, emotional and associative activity but do not know precisely how they work. A number of serious diseases are directly linked to these areas, including Parkinson’s, Tourette syndrome and obsessive-compulsive disorders (OCD). Existing treatments for regulating and measuring the activity of the subcortical areas are highly invasive, and sometimes work without us really knowing how. Researchers from the University of Geneva (UNIGE), Switzerland, and Cologne University (Germany) decided to see whether a non-invasive method – electroencephalography (EEG) – could be employed in tandem with mathematical algorithms to measure this brain activity externally. They proved for the first time that this technique is able to record signals usually only seen by implanting electrodes in the brain. The results, published in Nature Communications, pave the way for new, precision clinical applications.

It is very difficult to study and get close to the subcortical areas, which are located in the deepest part of the brain. We know that two key structures in these areas, the thalamus and nucleus accumbens, communicate with each other and the cortex to control motor, emotional and associative activation (higher-level thinking) via electrical oscillations. “A dysfunction in this communication causes very serious diseases in humans, such as Tourette’s and OCD, which generally begin in adolescence when the brain’s development comes to an end, as well as Parkinson’s disease”, explains Christoph Michel, a professor in the Department of Basic Neurosciences in UNIGE’s Faculty of Medicine.

Current treatments, based on deep brain stimulation are highly invasive: implanting electrodes into the centre of the brain, which are stimulated electrically by an external stimulator. “Although this technique has been shown to be effective in Parkinson’s, unfortunately it doesn’t work so well for OCD and Tourette syndrome,” says Martin Seeber, a researcher in the Department of Basic Neurosciences and the study’s first author.

An established and truly non-invasive analysis technique

To improve existing treatments, it has become essential to understand how these subcortical zones function and how they communicate. The diseases mentioned above only affect humans, however, and suffer from insufficient animal models. Since implanting electrodes is an extremely invasive technique, another method was called for to increase the number of subjects studied. “We naturally thought of EEG, which records the electrical activity of the brain using 256 electrodes placed on the scalp,” continues Michel. But is it really possible to measure deep brain activity from outside the skull?


The electroencephalogram records the electrical activity of the brain in a non-invasive way using 256 electrodes placed on the scalp. Thanks to mathematical algorithms combined with anatomical imaging, we can see what is happening in the deepest part of our brain, without having to enter it directly.NeuroscienceNews.com image is credited to UNIGE.

In collaboration with a team headed by professor Veerle Visser-Vanderwalle, a neurosurgeon at the University of Cologne, the UNIGE researchers were able to measure and record the electrical activity of the subcortical areas of four OCD and Tourette’s patients who had been given electrode implants. At the same time, these individuals were equipped with an EEG as the scientists measured the activity of the same areas from the surface. “The mathematical algorithms that we developed meant we could accurately interpret the data provided by the EEG and ascertain where the brain activity was coming from,” says Seeber. And the verdict? The results correlated perfectly. “In obtaining highly similar signals as with the implants, we finally proved that surface EEG can be used to see what is happening in the deepest part of the brain without having to go into it directly!” says professor Michel.

The door is open to new precision treatments

“Now that we know that EEG can be used to analyse the subcortical zones,” continues Seeber, “we can try to understand how they communicate with each other and the cortex in the hope that we’ll be able to better understand the causes of diseases such as Tourette’s and OCD.” The scientists are also keen to use the technique to improve current treatment methods, based on rebalancing network interactions using a very slight electric shock. They would also like to apply them to other diseases such as obesity, addiction or Alzheimer’s. “Lastly, we hope that in time we’ll be able to stimulate the deep brain areas from the surface via an electromagnetic treatment, doing away with electrode implants in the brain once and for all!” concludes professor Michel.

About this neuroscience research article

Source: Christoph Michel – University of Geneva
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is credited to UNIGE.
Original Research: Open access research for “Subcortical electrophysiological activity is detectable with high-density EEG source imaging” by Martin Seeber, Lucia-Manuela Cantonas, Mauritius Hoevels, Thibaut Sesia, Veerle Visser-Vandewalle & Christoph M. Michel in Nature Communications. Published February 14 2019.

Cite This NeuroscienceNews.com Article
University of Geneva “A Gentle Method For Unlocking the Mysteries of the Deep Brain.” NeuroscienceNews. NeuroscienceNews, 27 February 2019.
University of Geneva (2019, February 27). A Gentle Method For Unlocking the Mysteries of the Deep Brain. NeuroscienceNews. Retrieved February 27, 2019 from http://neurosciencenews.com/deep-brain-mystery-10828/
University of Geneva “A Gentle Method For Unlocking the Mysteries of the Deep Brain.” http://neurosciencenews.com/deep-brain-mystery-10828/ (accessed February 27, 2019).


Subcortical electrophysiological activity is detectable with high-density EEG source imaging

Subcortical neuronal activity is highly relevant for mediating communication in large-scale brain networks. While electroencephalographic (EEG) recordings provide appropriate temporal resolution and coverage to study whole brain dynamics, the feasibility to detect subcortical signals is a matter of debate. Here, we investigate if scalp EEG can detect and correctly localize signals recorded with intracranial electrodes placed in the centromedial thalamus, and in the nucleus accumbens. Externalization of deep brain stimulation (DBS) electrodes, placed in these regions, provides the unique opportunity to record subcortical activity simultaneously with high-density (256 channel) scalp EEG. In three patients during rest with eyes closed, we found significant correlation between alpha envelopes derived from intracranial and EEG source reconstructed signals. Highest correlation was found for source signals in close proximity to the actual recording sites, given by the DBS electrode locations. Therefore, we present direct evidence that scalp EEG indeed can sense subcortical signals.

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