Network Dynamics with BrainX3

A large scale simulation of the human brain network with real time interaction.

In order to address the big data challenge of the human brain, researchers at the SPECS lab of Paul Verschure have recently developed BrainX3, which is a platform for visualization, simulation, analysis and interaction of large data, that combines computational power with human intuition in representing and interacting with large complex networks. BrainX3 serves as a hypotheses generator of big data. As is often the case with complex data, one might not always have a specific hypothesis to start with. Instead, discovering meaningful patterns and associations in big data might be a necessary incubation step for formulating well-defined hypotheses.

On this platform, the researchers reconstructed a large-scale simulation of human brain activity in a 3D virtual reality environment. Using the brain’s known connectivity along with detailed biophysics, the researchers reconstruct neuronal activity of the entire cortex in the resting-state. Users can interact with BrainX3 in real-time by perturbing brain regions with transient stimulations to observe reverberating network activity, simulate lesion dynamics or implement network analysis functions from a library of graph theoretic measures. Within the immersive mixed/virtual reality space of BrainX3 users can explore and analysis dynamical activity patterns of brain networks, both at rest or during task, or for discovering of signaling pathways associated to brain function and/or dysfunction or as a tool for virtual neurosurgery.

The image shows a representation os a person touching computer generated images.
On this platform, the researchers reconstructed a large-scale simulation of human brain activity in a 3D virtual reality environment. Image adapted from the SPECS Lab/UPF Barcelona press release.

Besides the dynamics of the resting-state, on BrainX3, the researchers have also simulated neural activity from lesioned brains and that resulting from TMS perturbation. These simulations shed insight on the spatial distribution of activity in the attractor state, how the brain maintains a level of resilience to damage, effects of noise and physiological perturbations. Knowledge of brain activity in these various states is clinically relevant for assessing levels of consciousness in patients with severe brain injury.

About this big data research

We would like to thank Xerxes D. Arsiwalla for submitting this article to
Contact: Xerxes D. Arsiwalla – SPECS Lab/UPF Barcelona
Source: SPECS Lab/UPF Barcelona press release
Image Source: The image is adapted from the SPECS Lab/UPF Barcelona press release
Original Research: Abstract for “Network Dynamics with BrainX3: A Large-Scale Simulation of the Human Brain Network with Real-Time Interaction” by Xerxes D. Arsiwalla, Riccardo Zucca, Alberto Betella, Enrique Martinez, David Dalmazzo, Pedro Omedas, Gustavo Deco and Paul F. Verschure in Frontiers in Neuroinformatics. Published online February 2 2015 doi:10.3389/fninf.2015.00002

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