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NMDA receptors

This shows a rendering of an NMDA receptor

·November 2, 2022·3 min read

A New Look at Brain Function and Psychiatric Disorders

Researchers have revealed the 3D structure of NMDA receptor molecules that are critical for brain health. NMDA receptors are believed to contribute to a range of neurological and psychiatric disorders, including schizophrenia, depression, stroke, and Alzheimer's disease. The new model could help with the development of novel treatments for neuropsychiatric disorders.

Featured Neurology Neuroscience

·July 10, 2019·3 min read

Brain on Fire: Puzzling brain disease could now be better diagnosed and treated

A rare autoimmune disorder popularized by the autobiography and movie "Brain on Fire" is triggered by an attack on NMDA receptors. The disease occurs when antibodies attack NMDA receptors in the brain, leading to memory loss, intellectual changes, seizures, and death.

Featured Neurology Psychology

·August 6, 2012·8 min read

Brain Signal IDs Responders to Fast-Acting Antidepressants

Scientists have discovered a biological marker that may help to identify which depressed patients will respond to an experimental, rapid-acting antidepressant like ketamine. The brain signal, detectable by noninvasive imaging, also holds clues to the agent's underlying mechanism, which are vital for drug development, say NIH researchers.

Featured Neurology

·October 3, 2012·3 min read

Drug Reverses Abnormal Brain Function in Rett Syndrome Mice

in a mouse model of Rett syndrome, researchers were able to reverse abnormalities in brain activity and improve neurological function by treating animals with an FDA-approved anesthesia drug, ketamine.

Featured Neuroscience Open Neuroscience Articles Psychology

·April 26, 2020·4 min read

Effects of rapid-acting antidepressant ketamine consolidated in sleep?

Brain connections strengthened with treatment from fast-acting antidepressants, such as ketamine, are consolidated during deep sleep. Researchers propose rapid antidepressant treatments share the ability to regulate both synaptic potentiation and homeostatic mechanisms, which may contribute to how the brain reorganizes its activity to defeat depression.

This image shows words associated with PTSD arranged in the shape of a brain.

Featured Open Neuroscience Articles Psychology

·August 27, 2014·4 min read

Erasing Traumatic Memories

Researchers report xenon gas, normally used in humans for anesthesia, could potentially be used to treat PTSD.

The image shows a synaptic cleft. The caption best describes the image.

Featured Neuroscience

·February 4, 2013·4 min read

Finding the Way to Memory

A new study reveals DCC, the receptor for a crucial protein in the nervous system known as netrin, plays a key role in regulating the plasticity of nerve cell connections in the brain.

Featured Neuroscience

·September 19, 2016·4 min read

Glutamate Plays Previously Unknown Role in Neuromuscular Development

A new study looks at the role glutamate plays in neuromuscular development.

Auditory Neuroscience Featured Neuroscience Neuroscience Videos Psychology

·December 3, 2016·4 min read

Hearing Deficits in Schizophrenia Tied to Specific Brain Receptor

Dysfunctional NMDA brain receptors appear to be responsible for common hearing problems in people with schizophrenia, researchers report.

This shows a finger touching a drawing of a brain

Featured Neuroscience

·December 2, 2022·4 min read

How Ketamine Acts as a ‘Switch’ in the Brain

Ketamine alters neural activity in the cerebral cortex, silencing normally active neurons and activating neurons that are normally inactive. The ketamine activity-induced "switch" in brain regions associated with depression may help explain its treatment effects.

Featured Psychology

·August 17, 2015·1 min read

Mechanism that Triggers Disruption in Neural Communication Channels in Schizophrenia Identified

Researchers have identified a mechanism which triggers the disruption in the brain's communication channels that occurs in schizophrenia.

This shows the outline of a head made up of bubbles

Featured Neuroscience Open Neuroscience Articles Psychology

·April 16, 2022·6 min read

Modulating NMDA Receptor Activity Is the Key to Successful Treatment of PTSD

NYX-783, a newly discovered drug, helps modulate NMDA receptor function in neurons. The drug appears to be effective at suppressing the return of PTSD symptoms in rodent models.

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NMDA receptors

A New Look at Brain Function and Psychiatric Disorders

Brain on Fire: Puzzling brain disease could now be better diagnosed and treated

Brain Signal IDs Responders to Fast-Acting Antidepressants

Drug Reverses Abnormal Brain Function in Rett Syndrome Mice

Effects of rapid-acting antidepressant ketamine consolidated in sleep?

Erasing Traumatic Memories

Finding the Way to Memory

Glutamate Plays Previously Unknown Role in Neuromuscular Development

Hearing Deficits in Schizophrenia Tied to Specific Brain Receptor

How Ketamine Acts as a ‘Switch’ in the Brain

Mechanism that Triggers Disruption in Neural Communication Channels in Schizophrenia Identified

Modulating NMDA Receptor Activity Is the Key to Successful Treatment of PTSD

Reading Fiction Can Rewire Real-World Forgiveness and Empathy

PCOS/PMOS Increases Alzheimer’s Risk

Alcohol Tricks Brain Cells Into Destroying Themselves

Daytime Napping Linked to Higher Risk of Dementia

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