Targeting and reducing the methylation of a key mRNA promoted the migration of macrophages in the brain and can improve cognitive symptoms of Alzheimer's disease.
A novel mRNA delivery method that uses extracellular vesicles initiates collagen replacement in photoaged skin. A single injection increased collagen production and reduced wrinkle formation in targeted areas for two months. Researchers say the new delivery method could be used to treat a number of disorders including ones associated with protein loss associated with aging and hereditary disorders where genes and proteins are missing.
Using animal models, researchers demonstrate a potentially effective approach to treating blindness associated with genetic conditions by using mRNA and lipid nanoparticles.
A new study will explore the genesis of pain on a molecular and cellular level, with the goal of finding new treatments for chronic pain conditions.
mRNA decay may facilitate tau-induced damage to the brain and associated apoptosis that contributes to a range of neurodegenerative disorders. Researchers found the mechanism can be altered pharmacologically, providing a new target for the development of therapeutics to prevent or slow the progression of some neurodegenerative disorders.
A new study reveals why some people with the herpes simplex 1 virus experience painful lesions, while others have no symptoms and yet still spread the infection. Researchers say the difference could be a result of how variations in the way certain strains of HSV-1 activate gene expression in neurons.
When injected with the new mRNA vaccine, mice with multiple sclerosis-like symptoms developed less severe symptoms than would normally occur.
Rat model study reveals printer toner nanoparticles may change both genetic and metabolic profiles, making disease more likely.
Teenage binge drinking is linked to altered gene expression in the brain, specifically the central nucleus of the amygdala. Adolescent rats exposed to alcohol had increased levels of miR-137, resulting in lower expression of proteins essential for healthy neuron growth. During adulthood, these rats displayed higher levels of anxiety and an increased preference for alcohol consumption.
Study identifies a specific gene in rats that relates to physical inactivity. The gene could play a role in human sedentary behaviors.
S1PR3, a receptor found on the surface of brain cells, may play a key role in stress resilience. Veterans with severe PTSD symptoms had lower levels of the S1PR3 protein in their blood than peers without the disorder.
Oxytocin, a hormone commonly associated with love and bonding in humans, causes starfish to turn their stomachs inside-out to feed. The findings provide vital new evidence for the evolutionary role of oxytocin and vasopressin neuropeptides as regulators of feeding in animals.
