New findings reinforce the idea that dementia with Lewy bodies can be pathologically classified as two different and distinct disease types.
Study identified five genes, including two novel genes, associated with Lewy Body dementia. Researchers also found the genetic profiles of patients with LBD showed higher chances of also suffering from Alzheimer's and Parkinson's disease than other age-matched control subjects.
Researchers have created an artificial enzyme that stops alpha-synuclein from spreading. The findings could have positive implications for the treatment of Parkinson's disease.
Researchers have discovered a series of misfolded alpha-synuclein protein structures never previously observed. The alpha-synuclein fibers were larger than previously reported and adopted a striking variety of shapes. The work lays the foundation for a detailed analysis of misfolded alpha-synuclein structures and could provide a better understanding of the neurobiology of Parkinson's disease.
Natural killer cells may play a critical role in regulating and restraining neuroinflammation and protein clumping associated with Parkinson's disease.
Inflammation of the colon is associated with alterations in alpha-synuclein expression and phosphorylation in the myenteric plexus of common marmoset monkeys. The findings support the growing body of evidence that inflammation may play a role in the development of Parkinson's disease.
A new study reveals a defective version of astrocytes may be linked to the build up of alpha synuclein and could spur Parkinson's disease. The findings show the important role glial cells play in Parkinson's and offers insights into new targets for therapies to fight the neurodegenerative disease.
Researchers report those who have had appendectomies have a reduced risk of developing Parkinson's disease. A new study reveals the appendix acts as a reservoir for proteins associated with the neurodegenerative disease.