Using stem cells from candidates with Down syndrome to create an organoid, and employing mouse models, researchers pinpoint a gene linked to memory impairments and cognitive problems in Down syndrome. Inhibiting the OLIG2 gene leads to cognitive and memory improvements in mouse models of Down. Researchers hope their findings lead to an in utero treatment that targets the gene and helps reverse abnormal brain development.
A new study reports amyloid precursor proteins modulate neural signal transmission by binding to a specific receptor. Researchers say modulating the receptor could help treat Alzheimer's disease.
Researchers report extra copies of genes on chromosome 21 increase Alzheimer's like pathology and cognitive impairment in mouse models of Down syndrome. The findings provide insight into early onset Alzheimer's in those with Down syndrome.
Finding could explain the human sex ration that slightly favors males over females.
A new study of gene activity in the brains of people with Down syndrome reveals the formation of white matter is affected throughout life.
A new study sheds light into a possible cause of learning difficulties in Down syndrome.
Study reveals how the SNX27 protein regulates the generation of beta amyloid.
According to a new study, over-expression of the Usp16 gene could be a major contributor to neurological deficits associated with Down syndrome.