Engram cells encode details of memories as they are formed. These cells become reactivated when a memory is recalled. The process is controlled by remodeling of chromatin in the cells.
Study finds allele-specific open chromatin variants are likely to be linked to several neuropsychiatric traits and illnesses, including schizophrenia and bipolar disorder.
Blood vessels can sense the metabolic state of nearby neurons. An imbalance of fatty acids is sensed by neural blood vessels, stimulating them to mount a stress response by loosening the blood-brain barrier. If the imbalance remains, the leaky blood-brain barrier can induce a disease state.
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Using artificial intelligence, researchers discover mutations in noncoding regions of the human genome that may result in autism. The noncoding mutations are associated with altered gene regulation in children with ASD. Additionally, the mutations affect gene expression in the brain and genes already linked to autism, such as those responsible for neuron development and migration.
A cluster of epigenetic marks in an enhancer at IGF2 could enhance dopamine synthesis associated with psychosis in schizophrenia and bipolar disorder. The findings may help in devising more effective treatments and screening strategies for both disorders.
Researchers report stress during fetal development and early childhood can have lasting implications for brain development, leading to increased risks of brain disorders later in life.
Researchers have identified a genetic overlap between rheumatoid arthritis and Huntington's disease. The findings could open the door to developing new therapeutic targets and medications to combat both conditions.
Researchers have identified a molecule in white matter that prevents the brain from repairing itself following injury. By blocking the production of the molecule, researchers say it may allow an effective pathway for neuroregeneration.
Researchers have created a map of gene regulation in human cortical neurogenesis. The study reveals a number of factors that govern brain growth and the development of some brain disorders.