Study finds allele-specific open chromatin variants are likely to be linked to several neuropsychiatric traits and illnesses, including schizophrenia and bipolar disorder.
Researchers have succeeded in inducing one species of flatworm to grow heads and brains characteristic of another species of flatworm without altering genomic sequence.
Researchers report they are able to see alterations in gene expression up to two hours after a stickleback fish interacts with an intruder. They speculate the changes in gene expression and chromatin modification could help set up the brain to respond to future threats. The study appears in PLOS Genetics.
Blood vessels can sense the metabolic state of nearby neurons. An imbalance of fatty acids is sensed by neural blood vessels, stimulating them to mount a stress response by loosening the blood-brain barrier. If the imbalance remains, the leaky blood-brain barrier can induce a disease state.
Researchers report they have used an anti cancer drug to improve mental function in mice with genetic changes similar to those found in Kabuki syndrome.
A cluster of epigenetic marks in an enhancer at IGF2 could enhance dopamine synthesis associated with psychosis in schizophrenia and bipolar disorder. The findings may help in devising more effective treatments and screening strategies for both disorders.
Researchers report stress during fetal development and early childhood can have lasting implications for brain development, leading to increased risks of brain disorders later in life.