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          Alzheimer’s disease

          This shows a brain and DNA.
          FeaturedGeneticsNeurologyNeuroscience
          ·April 25, 2025·7 min read

          AI Uncovers New Cause of Alzheimer’s

          Researchers have discovered that a gene previously seen as a biomarker for Alzheimer’s disease, PHGDH, actually plays a causal role by disrupting gene regulation in the brain. Using AI, the team revealed that PHGDH has a hidden DNA-binding function unrelated to its known enzymatic activity. This malfunction triggers early Alzheimer’s development, offering a new target for prevention.
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          This shows an older lady exercising and a brain.
          FeaturedNeurologyNeuroscience
          ·April 25, 2025·9 min read

          Low and Moderate Exercise May Help Prevent Alzheimer’s Decline

          New findings from the EXERT study reveal that both low and moderate-high intensity exercise may help preserve cognitive function in older adults with mild memory problems, a major risk factor for Alzheimer’s disease. Over 12 months, participants who engaged in either form of exercise showed significantly less cognitive decline and reduced brain volume loss, especially in the prefrontal cortex, compared to a usual-care group.
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          This shows a blue brain.
          Neuroscience
          ·April 25, 2025·5 min read

          Blue Brain Marker Peaks in Midlife, May Predict Cognitive Aging

          Researchers have mapped age-related changes in the brain’s locus coeruleus (LC), a region linked to cognition and Alzheimer’s risk, by tracking neuromelanin, a pigment that gives it its signature blue hue. In a diverse group of participants aged 19 to 86, they found an inverted U-shaped pattern: LC signal peaked in late middle age, then declined.
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          This shows a woman and a brain.
          FeaturedNeurologyNeuroscience
          ·April 24, 2025·3 min read

          Metabolic Syndrome in Midlife Linked to Higher Dementia Risk

          A large-scale study has found that having metabolic syndrome in midlife—marked by excess belly fat, high blood pressure, and abnormal cholesterol or blood sugar—is associated with a significantly higher risk of developing young-onset dementia before age 65. The analysis, based on nearly two million people, showed that the more components of metabolic syndrome a person had, the greater their dementia risk, with women and those in their 40s being most vulnerable.
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          This shows a brain.
          FeaturedNeurologyNeuroscience
          ·April 24, 2025·5 min read

          Experimental Alzheimer’s Vaccine Shows Promise

          Researchers have developed a tau-targeting vaccine that could help prevent the progression of Alzheimer’s disease by generating a strong immune response against abnormal tau proteins. The vaccine showed effectiveness in mice and non-human primates, prompting researchers to pursue human clinical trials.
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          This shows a neuron.
          FeaturedGeneticsNeurologyNeuroscience
          ·April 22, 2025·5 min read

          Microglia Reprogrammed to Deliver Precision Alzheimer’s Therapies

          Researchers have developed engineered human microglia that detect disease-related brain changes and release therapeutic proteins precisely where needed. Using CRISPR technology, the team programmed these cells to secrete an enzyme that breaks down beta-amyloid plaques only in affected areas.
          Read More
          This shows two brains.
          FeaturedNeurologyNeuroscience
          ·April 21, 2025·6 min read

          Early Alzheimer’s Clues Found in Adults as Young as 24

          A new study reveals that cognitive changes tied to Alzheimer's risk factors begin far earlier in life than previously thought, some as early as age 24. Researchers found associations between memory performance and cardiovascular risk factors, immune markers, and Alzheimer’s biomarkers (amyloid, tau, and neurodegeneration) in individuals aged 24–44.
          Read More
          This shows a brain and the outline of a person.
          FeaturedGeneticsNeurologyNeuroscience
          ·April 17, 2025·3 min read

          How Age, Sex, and Genetics Shape Blood Biomarkers for Dementia

          A new study reveals how age, sex, menopause, and genetics influence key blood biomarkers linked to dementia risk. Researchers analyzed data from over 1,000 people, measuring three biomarkers over a 17-year period and comparing results between those who developed dementia and those who did not.
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          This shows two women and a brain.
          FeaturedNeurologyNeuroscience
          ·April 16, 2025·5 min read

          Ozempic Linked to Lower Alzheimer’s Risk

          A new study suggests that two widely used Type 2 diabetes medications—GLP-1 receptor agonists and SGLT2 inhibitors—may help reduce the risk of Alzheimer’s disease and related dementias. Researchers analyzed Medicare data and found that patients taking these drugs had significantly lower rates of cognitive decline compared to those using other glucose-lowering medications.
          Read More
          This shows a woman playing guitar.
          FeaturedNeurologyNeurosciencePsychology
          ·April 16, 2025·4 min read

          From Anxiety to Alzheimer’s, Music Makes a Difference

          Music therapy is proving to be a powerful adjunct treatment for a range of conditions, including Alzheimer’s disease, chronic pain, movement disorders, and mental health issues. Research highlights how music can regulate heart rate, reduce anxiety, and even improve communication in patients with memory loss.
          Read More
          This shows a brain scan.
          FeaturedNeurologyNeuroscience
          ·April 16, 2025·5 min read

          AI Tool Predicts Toxic Protein Structures Behind Brain Disorders

          A new AI tool called RibbonFold is revolutionizing how scientists understand misfolded proteins linked to Alzheimer’s and Parkinson’s. Unlike existing tools such as AlphaFold, which predict correctly folded proteins, RibbonFold is specifically designed to model the twisted, ribbonlike shapes of amyloid fibrils that accumulate in neurodegenerative diseases.
          Read More
          This shows a head and musical icons.
          FeaturedNeurologyNeuroscience
          ·April 15, 2025·4 min read

          Why Nostalgic Songs Spark the Brain’s Memory and Reward System

          Listening to nostalgic music activates key brain regions tied to memory and emotion, according to a new brain imaging study. Researchers found that songs linked to personal memories engage both the default mode network and the brain's reward circuitry.
          Read More
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          This is a drawing of a shrew and a brain.

          Shrews Shrink and Regrow Brains, Offering Clues for Human Diseases

          This shows the outline of a person with a glowing brain and a robotic arm.

          Brain-AI System Translates Thoughts Into Movement

          This shows a brain with two paths leading to it.

          Depression Disrupts Learning to Avoid Unpleasant Events

          This shows a map, half Is red and covered in negative emojis, the other is blue and covered with positive emojis, symbolizing the effect heat has on mood.

          Extreme Heat Makes People More Negative

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