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Summary: A set of neurons in the basal forebrain may drive aversions to certain foods.
Source: Baylor College of Medicine
After fasting for 24 hours the typical laboratory mouse spends much time eating. Surprisingly, this is not what Jay M. Patel saw when he was studying basal forebrain circuits in mice.
“When I joined Dr. Benjamin Arenkiel’s lab, they had just discovered a unique set of circuits in the basal forebrain, a region separate from the hypothalamus, the brain area that normally regulates how much you eat depending on how much energy you spend,” said Patel, a student in the neuroscience Medical Scientist Training Program (M.D./Ph.D.) at Baylor College of Medicine. “I wanted to investigate what these circuits that are linked to the feeding center of the brain were actually doing.”
Using cutting-edge technologies, including microendoscopy-imaging protocols, Patel and his colleagues first investigated what types of stimuli would activate the circuits. By recording the activity of the neurons, Patel found that food odors highly activated a subset of neurons in the basal forebrain identified by the expression of the molecule vGlut2.
“That was very interesting because we know that the sense of smell can drive appetite. For instance, after smelling dessert, you may want to eat it even though you just had a big meal. Or conversely, after smelling a spoiled dish you won’t eat it, even if you are very hungry,” Patel said.
Although researchers knew that the perception of food odors itself can affect neuronal activity in the hypothalamus, it was unclear how odor perception was relayed to the hypothalamus. They were excited at the possibility that the novel vGlut2+ basal forebrain circuits might provide an answer.
Patel and his colleagues studied the effect of specifically activating vGlut2+ neurons in the basal forebrain and observed dramatically altered feeding behavior in mice.
“Surprisingly, four to five days after we began the experiment, the mice started to lose weight quickly,” Patel said.
The researchers determined that the animals’ rapid weight loss could not be explained by metabolic dysfunction, as they found no differences between the levels of pituitary or thyroid hormones, or in the levels of glucose, insulin or leptin between the experimental and control groups. The mice lost weight rapidly because they had stopped eating.
“They did not eat even when they were hungry, which we found remarkable because animals are compelled to eat to survive,” Patel said. Interestingly, further experiments showed that naturally aversive odors had a stronger effect on vGlut2+ basal forebrain neurons than food alone, triggering a food avoidance behavior in mice.
“It seemed that the animals were afraid of food,” Patel said. “Even though they were hungry, they avoided locations where food was placed.”
“We have identified a brain circuit driven by vGlut2+ neurons in the basal forebrain that suppresses appetite when it’s active and stimulates feeding behavior when it’s inactive,” Patel said. “We also determined that this circuit, which is formed by just a couple of thousand neurons involved in perceiving the outside world, connects with and overrides feeding behaviors regulated by the hypothalamus.”
“We think this work has potential implications that reach beyond feeding behaviors and mouse physiology,” said Arenkiel, associate professor of neuroscience and molecular and human genetics and a McNair Scholar at Baylor. He is also a member of the Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital. “This circuit is highly involved with how our brain perceives the outside world and brings this information to the hypothalamus, thus connecting with aspects of physiology like feeding, which relates to eating disorders that are associated with many neuropsychiatric conditions.”
Other contributors to this work include Jessica Swanson, Kevin Ung, Alexander Herman, Elizabeth Hanson and Joshua Ortiz-Guzmán, all affiliated with Baylor College of Medicine; Jennifer Selever (at Baylor and the Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital); and Qingchun Tong at University of Texas Health Science Center, Houston.
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Source: Baylor College of Medicine Media Contacts: Graciela Gutierrez – Baylor College of Medicine Image Source: The image is in the public domain.
Original Research: Open access “Sensory perception drives food avoidance through excitatory basal forebrain circuits”. Jay M Patel, Jessica Swanson, Kevin Ung, Alexander Herman, Elizabeth Hanson, Joshua Ortiz-Guzman, Jennifer Selever, Qingchun Tong, Benjamin R Arenkiel. eLife. doi:10.7554/eLife.44548
Sensory perception drives food avoidance through excitatory basal forebrain circuits
Appetite is driven by nutritional state, environmental cues, mood, and reward pathways. Environmental cues strongly influence feeding behavior, as they can dramatically induce or diminish the drive to consume food despite homeostatic state. Here, we have uncovered an excitatory neuronal population in the basal forebrain that is activated by food-odor related stimuli, and potently drives hypophagia. Notably, we found that the basal forebrain directly integrates environmental sensory cues to govern feeding behavior, and that basal forebrain signaling, mediated through projections to the lateral hypothalamus, promotes selective avoidance of food and food-related stimuli. Together, these findings reveal a novel role for the excitatory basal forebrain in regulating appetite suppression through food avoidance mechanisms, highlighting a key function for this structure as a potent integrator of sensory information towards governing consummatory behaviors.
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