Genetic Link Between Eating Disorders and Alcohol Use Discovered

Summary: A comprehensive study of adolescent twins unveils a genetic nexus between disordered eating and alcohol use disorders (AUDs). This correlation underscores worse outcomes, including fatality, especially when these conditions manifest simultaneously in younger teens.

The study, conducted in the U.S. and Sweden, showcased how these intertwined disorders are influenced differently in males and females. The research emphasizes the significance of sex-specific treatment strategies.

Key Facts:

  1. The study highlighted a clear phenotypic correlation between disordered eating and alcohol use across various manifestations in females.
  2. Twin studies, a fundamental tool in this research, assist in discerning between genetic and environmental influencers.
  3. While nonshared environmental influences contribute to the disorders individually, they marginally influence their concurrent appearance, particularly in women.

Source: Research Society on Alcoholism

Certain genetic influences contribute to disordered eating and problematic alcohol use, leaving some people vulnerable to both conditions, according to a large study of late adolescent twins.

Previous research has found concurrent eating disorders and risky drinking in younger teens amplify the chance of worse outcomes, including death. Studies across age groups have pointed to shared genetic influences for the two conditions, and other studies suggest that changes in one disorder may aggravate symptoms in the other.

This shows a woman with glasses of wine and a plate of food.
The study points to the importance of sex-specific treatment strategies for late adolescents with concurrent disordered eating and problematic alcohol use. Credit: Neuroscience News

Understanding the genetic and environmental factors involved in co-occurring eating disorders and alcohol use disorders (AUDs) could improve treatment and outcomes.

Adolescence is a key life stage for onset, and the major transitions characterizing the late teen years may heighten susceptibility. Little is known, however, about the varying manifestations and combinations of eating disorders and AUDs in late adolescence or potential sex differences.

For the study published in Alcohol: Clinical and Experimental Research, investigators in the U.S. and Sweden examined genetic and environmental risks across various dimensions and measures of disordered eating and drinking in 18-year-old twins.

Twin studies are a vital tool for differentiating between genetic and environmental influences. The researchers worked with 3,568 female and 2,526 male same-sex twins in Sweden.

The participants completed surveys assessing their drive for thinness, bulimia, body dissatisfaction, alcohol consumption over the last year (frequency and amount), and alcohol problems over the previous year (signs of dependence and harmful use).

Investigators looked for three types of influence: evidence of multiple genes that work together to affect relevant traits; shared environmental factors, such as socioeconomic status, making twins more similar for a given trait; and nonshared environmental factors (e.g., childhood trauma and peer influences), making twins more dissimilar for a given trait.

They used statistical analysis to quantify the genetic and environmental contributions to disordered eating associated with alcohol use.

Co-occurring disordered eating and alcohol involvement manifested differently in male and female twins. In the women, the phenotypic correlation between the conditions was evident across different manifestations of disordered eating and alcohol use. In the men, the association was specific to problematic alcohol use.

In young women (but not the men), drive for thinness, bulimia, and body dissatisfaction had slight-to-moderate genetic correlations with alcohol consumption and problems.

Overall, nonshared environmental influences contributed to separate disordered eating dimensions and alcohol measures but minimally contributed to the co-occurrence of the two conditions in the women. Some findings contrasted with previous research involving 16- and 17-year-old twins, possibly reflecting differences in alcohol use relating to the legal drinking age in Sweden (18).

The study points to the importance of sex-specific treatment strategies for late adolescents with concurrent disordered eating and problematic alcohol use. Additionally, the findings could help identify vulnerable teens.

Late adolescents presenting with symptoms of disordered eating or problematic alcohol use could be screened for the other condition, potentially improving detection and treatment. Assessing the family history of multiple eating disorder manifestations also has value in screening and treatment.

The study did not identify specific genetic or environmental factors affecting co-occurring conditions. Further research is needed on potential differences between countries and regions and more diverse populations.

About this genetics and mental health research news

Author: Press Office
Source: Research Society on Alcoholism
Contact: Press Office – Research Society on Alcoholism
Image: The image is credited to Neuroscience News

Original Research: Closed access.
Differential genetic associations between dimensions of eating disorders and alcohol involvement in late adolescent twins” by Baiyu Qi et al. Alcohol: Clinical and Experimental Research


Abstract

Differential genetic associations between dimensions of eating disorders and alcohol involvement in late adolescent twins

Background

Twin studies have demonstrated shared genetic and environmental effects between eating disorders and alcohol involvement in adults and middle adolescents. However, fewer studies have focused on late adolescents or investigated a wide range of eating disorder dimensions and alcohol involvement subscales in both sexes. We examined genetic and environmental correlations among three eating disorder dimensions and two alcohol involvement subscale scores in late adolescent twins using bivariate twin models.

Methods

Participants were 3568 female and 2526 male same-sex twins aged 18 years old from the Child and Adolescent Twin Study in Sweden. The Eating Disorder Inventory-2 (EDI) assessed the drive for thinness, bulimia, and body dissatisfaction. Alcohol involvement was assessed with the Alcohol Use Disorder Identification Test consumption (AUDIT-C) and problem (AUDIT-P) subscales.

Results

Only phenotypic and twin correlations in female twins met our threshold for twin modeling. The proportion of total variance for each trait accounted for by additive genetic factors ranged from 0.50 to 0.64 in female twins, with the rest explained by nonshared environmental factors and measurement error. Shared environmental factors played a minimal role in the variance of each trait. The strongest genetic correlation (ra) emerged between EDI bulimia and AUDIT-P (ra = 0.46, 95% confidence interval: 0.37, 0.55), indicating that the proportion of genetic variance of one trait that was shared with the other trait was 0.21. Nonshared environmental correlations between eating disorder dimensions and alcohol involvement ranged from 0.03 to 0.13.

Conclusions

We observed distinct patterns of genetic and environmental effects for co-occurring eating disorder dimensions and alcohol involvement in female vs. male twins, supporting sex-specific treatment strategies for late adolescents with comorbid eating disorders and alcohol use disorder. Our findings emphasize the importance of assessing family history of multiple eating disorder dimensions while treating late adolescents with problematic alcohol use, and vice versa, to improve detection and treatment.

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