Neuroscience research articles are provided.
What is neuroscience? Neuroscience is the scientific study of nervous systems. Neuroscience can involve research from many branches of science including those involving neurology, brain science, neurobiology, psychology, computer science, artificial intelligence, statistics, prosthetics, neuroimaging, engineering, medicine, physics, mathematics, pharmacology, electrophysiology, biology, robotics and technology.
– These articles focus mainly on neurology research. – What is neurology? – Definition of neurology: a science involved in the study of the nervous systems, especially of the diseases and disorders affecting them. – Neurology research can include information involving brain research, neurological disorders, medicine, brain cancer, peripheral nervous systems, central nervous systems, nerve damage, brain tumors, seizures, neurosurgery, electrophysiology, BMI, brain injuries, paralysis and spinal cord treatments.
What is Psychology? Definition of Psychology: Psychology is the study of behavior in an individual, or group. Psychology news articles are listed below.
Artificial Intelligence articles involve programming, neural engineering, artificial neural networks, artificial life, a-life, floyds, boids, emergence, machine learning, neuralbots, neuralrobotics, computational neuroscience and more involving A.I. research.
Robotics articles will cover robotics research press releases. Robotics news from universities, labs, researchers, engineers, students, high schools, conventions, competitions and more are posted and welcome.
Genetics articles related to neuroscience research will be listed here.
Neurotechnology research articles deal with robotics, AI, deep learning, machine learning, Brain Computer Interfaces, neuroprosthetics, neural implants and more. Read the latest neurotech news articles below.
UCSF study shows measurable neurological differences in affected children.
Researchers at UC San Francisco have found that boys and girls with sensory processing disorder (SPD) have altered pathways for brain connectivity when compared to typically developing children, and the difference predicts challenges with auditory and tactile processing.
The research, published Jan. 26, 2016, in the journal Frontiers in Neuroanatomy, is the biggest imaging study ever done in children with SPD. It’s also the first to compare the white matter tracts in the brain of typically developing boys and girls versus those with an SPD diagnosis. The brain’s white matter forms the “wiring” that links different areas of the brain and is therefore essential for perceiving, thinking and action.
Children with SPD struggle with processing stimulation, which can cause a wide range of symptoms, including hypersensitivity to sound, sight and touch. Many affected children also have poor fine motor skills, such as problems with holding a pencil, challenges with attention and profound difficulties with emotional regulation. Some SPD children cannot tolerate the sound of a vacuum cleaner or the touch of their loved ones. Furthermore, a sound that is an irritant one-day can be tolerated the next making parenting very confusing.
The study enrolled 40 right-handed boys and girls with SPD and 41 right-handed typically developing children, and examined the pathways for connectivity of specific white matter tracts in their brain using diffusion tensor imaging (DTI). The SPD and control subjects’ behaviors were first characterized using a parent report measure of sensory behavior called the Sensory Profile. They also were given the Acoustic Index of the Differential Screening Test and a portion of the Sensory Integration Praxis Tests to directly measure auditory and tactile processing, respectively.
“By comparing the white matter in the brain of kids with SPD and typically developing kids, we were able to relate them to direct measurements of auditory and tactile function and find strong correlations between the white matter and sensory functioning,” said senior author Pratik Mukherjee, MD, PhD, a professor of radiology and biomedical imaging and bioengineering at UCSF. “The children with SPD and the typically developing kids form a continuum, with the children with SPD at one extreme and sensory-typical at the other. This builds on the idea that SPD is a spectrum disorder and for the first time we have direct measurements, rather than solely relying on parent reports.”
Examining Brain Wiring
The researchers used DTI to measure the structural connectivity of the kids in both groups. The advanced form of imaging measures the microscopic movement of water molecules within the brain and shows the direction of the white matter fibers and their integrity, thereby mapping the structural connections between brain regions. The microstructure of the white matter correlates with sensory functioning, especially in the back of the brain where tracts are responsible for relaying sensory information.
The imaging detected abnormal white matter tracts in the SPD subjects that serve as connections for the auditory, visual and somatosensory (tactile) systems involved in sensory processing, including their connections between the left and right halves of the brain. The abnormal microstructure of sensory white matter tracts shown by DTI in kids with SPD likely alters the timing of sensory transmission, so that processing of sensory stimuli and integrating information across multiple senses becomes difficult or impossible.
The results of the DTI had a stronger correlation with the direct measurements of tactile and auditory processing taken during the neurological testing than in the parent report survey, which the researchers say is likely due to the direct measurements being more objective.
“Knowing that the neurological testing is a strong predictor of what we’ll see on the DTI means we can use it more confidently to calculate sensory challenges, and tailor our treatments to best help our patients,” said Elysa Marco, MD, who led the study along with postdoctoral fellow Julia Owen, PhD, and Yi-Shin Chang, MS, in the department of radiology and biomedical imaging. “This ties directly into precision medicine – not relying on one size fits all for clinical diagnoses – but objectively assessing patients using quantifiable biomarkers to then personalize their treatment.”
This new research follows UCSF’s groundbreaking study published in 2013 that was the first to find that boys affected with SPD have quantifiable regional differences in brain structure when compared to typically developing boys. This work showed a biological basis for the disease but prompted the question of how these differences compared with other neurodevelopmental disorders and how it would manifest in girls.
SPD can be hard to pinpoint, as up to 90 percent of children with autism also are reported to have atypical sensory behaviors, and SPD has not been listed in the Diagnostic and Statistical Manual used by psychiatrists and psychologists. However, children with sensory-based dysfunction who do not meet the criteria for autism based on social communication deficits remain virtually unstudied.
[divider]About this neurology research[/divider]
The study’s co-authors are Yi-Shin Chang, MS; Julia Owen, PhD; Shivani Desai, BS; Anne Brandes-Aitkin, BS; Susanna Hill, BS; Anne Arnett, MA; and Julia Harris, BS, all of UCSF.
Funding: This work was funded by grants from the Wallace Research Foundation to EJM and to PM and a gift from Toby Mickelson and Donald Brody to EJM. EJM has received neuroimaging support that contributed to this work from NIH K23 MH083890. The researchers also received generous support from the SPD community of family and friends through gifts large and small to the UCSF Sensory Neurodevelopment and Autism Program (SNAP.) The authors have reported that they have no conflicts of interest relevant to the contents of this paper to disclose.
Source: Suzanne Leigh – UCSF Image Source: The image is credited to Mukherjee et al./Frontiers in Neuroanatomy Original Research: Full open access research for “White Matter Microstructure is Associated with Auditory and Tactile Processing in Children with and without Sensory Processing Disorder” by Yi-Shin Chang, Mathilde Gratiot, Julia P. Owen, Anne Brandes-Aitken, Shivani S. Desai, Susanna S. Hill, Anne B. Arnett, Julia Harris, Elysa J. Marco and Pratik Mukherjee in Frontiers in Neuroanatomy. Published online January 26 2016 doi:10.3389/fnana.2015.00169
White Matter Microstructure is Associated with Auditory and Tactile Processing in Children with and without Sensory Processing Disorder
Sensory processing disorders (SPDs) affect up to 16% of school-aged children, and contribute to cognitive and behavioral deficits impacting affected individuals and their families. While sensory processing differences are now widely recognized in children with autism, children with sensory-based dysfunction who do not meet autism criteria based on social communication deficits remain virtually unstudied. In a previous pilot diffusion tensor imaging (DTI) study, we demonstrated that boys with SPD have altered white matter microstructure primarily affecting the posterior cerebral tracts, which subserve sensory processing and integration. This disrupted microstructural integrity, measured as reduced white matter fractional anisotropy (FA), correlated with parent report measures of atypical sensory behavior. In this present study, we investigate white matter microstructure as it relates to tactile and auditory function in depth with a larger, mixed-gender cohort of children 8–12 years of age. We continue to find robust alterations of posterior white matter microstructure in children with SPD relative to typically developing children (TDC), along with more spatially distributed alterations. We find strong correlations of FA with both parent report and direct measures of tactile and auditory processing across children, with the direct assessment measures of tactile and auditory processing showing a stronger and more continuous mapping to the underlying white matter integrity than the corresponding parent report measures. Based on these findings of microstructure as a neural correlate of sensory processing ability, diffusion MRI merits further investigation as a tool to find biomarkers for diagnosis, prognosis and treatment response in children with SPD. To our knowledge, this work is the first to demonstrate associations of directly measured tactile and non-linguistic auditory function with white matter microstructural integrity – not just in children with SPD, but also in TDC.
“White Matter Microstructure is Associated with Auditory and Tactile Processing in Children with and without Sensory Processing Disorder” by Yi-Shin Chang, Mathilde Gratiot, Julia P. Owen, Anne Brandes-Aitken, Shivani S. Desai, Susanna S. Hill, Anne B. Arnett, Julia Harris, Elysa J. Marco and Pratik Mukherjee in Frontiers in Neuroanatomy. Published online January 26 2016 doi:10.3389/fnana.2015.00169
[divider]Feel free to share this neuroscience article.[/divider]