When T helper cells are absent in the brain, microglia remain suspended between the fetal and adult developmental state. Mice lacking brain T cells showed changes in behavior and defective synaptic pruning. The study reveals the critical role T cells play in the development of the brain.
Blood gene expression analysis uncovered a critical gene network that is disrupted in Autism. The disrupted gene network is related to fetal brain development and is also dysregulated in ASD cellular models. The findings provide further evidence that genetic factors influencing brain development during pregnancy are a primary cause of autism spectrum disorder.
Researchers have genetically modified white blood cells to produce GDNF and deliver it to the brain, a new study reports.
Researchers have been able to preserve cognition in mice exhibiting features of Alzheimer's disease.