c9ASO, an investigational ASO drug, targets the TDP-43 protein, reducing its buildup and decreasing neurological decline associated with ALS and FTD. Read More
Compared to typically developing children, those with disruptive behavioral disorders, characterized by antisocial behaviors and aggression, had less gray matter in the amygdala and hippocampus. Read More
Both food timing and the integrity of the internal clock in the liver altered rhythms of metabolism in mice. Almost half of the rhythmic genes are regulated by both the internal clock and when food is ingested. Read More
Researchers successfully applied a gene therapy platform to completely correct brain defects in a large animal model of a human genetic disease. Read More
The loss of the protein neurofibromin 1 (NF1) in adult male flies resulted in social impairments. The deficits were traced back to a primary disruption in a small group of peripheral neurons which control external stimuli, including touch and smell, that communicate to the brain. Read More
HIV infection leads to increased EIF2 signaling in microglia, astrocytes, and neurons. Study reveals how HIV infection and some antiretrovirals affect cognition and the central nervous system. Read More
Dantrolene, a common muscle relaxant, shows promise in the treatment of Alzheimer's disease. Mice administered the drug intranasally had higher concentrations of the medicine in their brains, and for longer periods, than those who received it orally. The drug has been shown to help inhibit or slow the progression of several neurodegenerative diseases. Read More
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Combining neuroimaging data with artificial intelligence, researchers have identified two distinct neuroanatomical subtypes of schizophrenia. The first, more typical subtype is associated with a lower widespread volume of gray matter compared to healthy controls. In the second subtype, gray matter volume is largely similar to healthy brains. Read More
Study shows how brain networks unique to each child can predict cognition. Using a combination of neuroimaging data and machine learning, researchers reveal functional neuroanatomy can vary greatly among children and is refined during development. Read More
Deleting the circadian rhythm-associated BMAL1 gene in animal models, researchers discovered tissue continued to follow a 24-hour rhythm, even in the absence of external stimuli that can influence the cycle. Read More
Contrary to the initial findings, a reanalysis of data from a 2019 study found no clear relationship between a rise in teenage suicide and the Netflix show "13 Reasons Why". Read More
Children who exhibit less fear and desire for social connection, and who engage less in imitative behaviors, are more likely to develop callous-unemotional traits which may later lead to antisocial behaviors. Read More
