Opiate exposure causes synaptic rewiring in the nucleus accumbens in addition to decreasing dendritic spines. The findings shed light into the neurobiology of opiate relapse.
Cognitive behavioral therapy for pain that is supported by artificial intelligence renders the same results as guideline-recommended programs while requiring less clinician time, thus making the option more accessible for patients.
Alterations in long-term social behavior and gene expression were observed in the offspring of mice exposed to pain-killing opioids during pregnancy.
A new study reports researchers have discovered a brain mechanism that could be a suitable target to prevent addiction and tolerance to opioids.
Almost 1 in 5 people now use opioids to treat migraines. Researchers say a growing number of patients are using opioids to replace medications approved and specially designed to treat migraines, despite knowing the risks of opioid use.
Researchers discover how sodium influences the signalling of opioid receptors.
Researchers find no evidence that long term or higher opioid use increases a person's risk of developing Alzheimer's disease.
35% of patients who used ketamine to manage pain reported significant side effects ranging from hallucination, out-of-body experiences, visual disturbances, and urinary dysfunction. 20% of the side effects were linked directly to ketamine, and 15% associated with ketamine in combination with other drugs.
Researchers have developed a new compound that selectively targets the brain's analgesic circuitry, but does not trigger potentially lethal side effects like traditional opioids.