Nicotine exposure significantly altered the metabolism and secretion of serotonin, acetylcholine, kynurenic acid, and choline in HT22 hippocampal cells. Findings suggest nicotine could have neuroprotective properties and provide cognitive enhancement.
Higher polygenetic risk scores for schizophrenia, depression, neuroticism, and alcohol use disorder are indicators for higher risk of nicotine dependence.
Flavored e-cigarette tobacco engages the taste system, while non-flavored vaped nicotine triggers the brain's reward system in a similar way observed when people smoke traditional cigarettes.
Between 60-90% of people with schizophrenia smoke, compared to between 15-24% of the general population. A new study found 40% of those with schizophrenia stopped smoking traditional cigarettes after 12 weeks of switching to e-cigarettes. Researchers also reported a significant number of participants sustained their reduction in smoking or completely stopped smoking at the end of the 12-week study.
A smoking cessation drug called cytisine may be a helpful new tool for the treatment of Parkinson's disease in women. Cytisine was found to reduce the loss of dopamine neurons. The effect was more pronounced when estrogen was present.
Mixing traditional cigarettes with vaping products is as detrimental to health as smoking cigarettes alone, a new study reports.
The way zebrafish respond to repeated exposure and withdrawal from nicotine mirrors more complex human responses during withdrawal.
Common green apple flavorant farnesene enhances nicotine reward in mouse models. The flavorant is also rewarding on its own. Researchers say with or without nicotine, flavored vapes, especially those containing farnesene, pose potential neurological risks, including addiction.
Episodic exposure to nicotine, caffeine, and amphetamines triggers malfunctions in the fetal brain, specifically affecting the development of the indusium griseum.
Consuming nicotine and alcohol four hours before bedtime causes worse sleep continuity and sleep disruptions. Surprisingly, researchers found no link between caffeine consumption four hours before sleep and sleep disturbances for most people.