Researchers have designed a new method of converting non-neural cells into functioning neurons that are able to form synapses, dispense dopamine, and restore the function of neurons undermined by Parkinson's associated destruction of dopaminergic cells.
A newly developed probiotic bacteria that can synthesize the dopamine precursor L-DOPA is safe, well-tolerated, and eliminates the side effects associated with L-DOPA use for Parkinson's disease.
Drugs that increase signaling of Sonic Hedgehog (Shh) can help suppress the involuntary movements associated with dopamine replacement therapy for those with Parkinson's disease.
Grafting neurons derived from a monkey's own stem cells reversed the debilitating and mental health symptoms associated with Parkinson's disease. The treatment shows promise for alleviating the symptoms of Parkinson's in humans.
Anti-psychotic drugs do not only block dopamine signaling in the brain, they also block dopamine signaling in the pancreas. Blocking dopamine signaling in the pancreas leads to uncontrolled production of blood-glucose regulating hormones, increasing obesity and diabetes risks.
Genetically modified tomatoes enriched with L-DOPA may become a new and more affordable source for the essential Parkinson's disease drug.
Parkinson's disease involves monocytic alterations in the blood. The cells have reduced viability and are unresponsive to specific stimuli, which could have relevant consequences for the progression of Parkinson's. Immune modulation medications may be a new treatment option to inhibit neurodegeneration associated with PD.
Selective estrogen treatments appear to reduce symptoms of Parkinson's disease in male mice. The study sheds light on sex-based differences associated with the disease and may provide new therapeutic avenues for treatment.
Open sharing of scientific data and standard methods will allow researchers to collaborate on projects and accelerate understanding of neurodegenerative diseases.
MIT researchers have developed a new ultra-thin needle capable of delivering drugs directly to the brain.