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fluoxetine

·April 5, 2023·3 min read

How Prozac Increases Brain Plasticity

Fluoxetine (Prozac), a common antidepressant, was found to enhance the erasure of learned fear responses and facilitate spatial pattern learning in mice. The study also found the TrkB receptor in PV+ interneurons plays a crucial role in these effects, which may offer new possibilities for the development of psychiatric treatments targeting brain plasticity.

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·October 21, 2021·4 min read

Prozac Pegged as Potential First Treatment for a Leading Cause of Blindness

Fluoxetine, the antidepressant commonly known as Prozac, may be beneficial for the treatment of age-related macular degeneration. Researchers found Prozac significantly slowed the rate at which people over 50 developed AMD.

Featured Neuroscience Psychology

·August 23, 2021·5 min read

Prozac Changes Fat Composition of the Brain

Prozac reduced polyunsaturated fatty acid lipid concentrations in the brains of juvenile macaque monkeys.

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·August 19, 2021·5 min read

Disturbed Circadian Rhythm May Be Associated With Alzheimer’s Disease

Long-term circadian rhythm disruptions induce Alzheimer's disease-like pathology in rats, which can be reversed by administering fluoxetine. Additionally, elevated levels of amyloid beta and circadian rhythm disruptions can trigger each other, leading to the cascade of neurological symptoms of dementia.

Featured Neuroscience Psychology

·January 8, 2020·5 min read

Are some antidepressants less risky for pregnant women?

Alteration of placental serotonin levels due to maternal depression or antidepressant use may be associated with the disruption of placental estrogen production.

Featured Neuroscience Psychology

·December 16, 2019·2 min read

The effect of taking antidepressants during pregnancy

Exposure to antidepressants during the first few weeks of pregnancy has long term implications for sensory processing in the offspring.

Featured Neuroscience Psychology

·September 6, 2019·5 min read

How serotonin and a popular anti-depressant affect the gut’s microbiota

Serotonin and SSRIs like Prozac can have a major effect on gut bacteria. When exposed to serotonin, specific gut bacteria grew to higher levels. However, when exposed to SSRIs, the bacterium grew to much lower levels in mouse models.

Featured Neuroscience Psychology

·July 10, 2019·2 min read

How a popular antidepressant drug could rewire the brain

Fluoxetine rearranges nerve fibers in the hippocampus of mice, a new study reports.

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Featured Neurology Neuroscience Open Neuroscience Articles Psychology

·June 25, 2019·4 min read

Common antidepressants interact with opioid med to lessen pain relief

SSRI antidepressants, such as Prozac and Paxil, interact with opioid medications to make them less effective at providing relief from chronic pain. Tramadol relies on activation of the CYP2D6 enzyme to control pain, but SSRIs inhibit this enzyme. Researchers suggest prescribing different classes of antidepressants which do not suppress the enzyme may benefit those in need of opioid medications. Alternatively, non-opioid pain killers should be considered for those who can not switch from SSRIs.

Autism Featured Neuroscience Open Neuroscience Articles Psychology

·April 30, 2019·4 min read

Possible link between autism and antidepressants use during pregnancy: Mouse Study

A new study in mice reveals a possible link between the use of SSRI antidepressants during pregnancy and an increased risk of autism-like symptoms in offspring. Offspring exposed to fluoxetine (Prozac) in utero were more likely to exhibit impaired neurotransmission caused by an overactive serotonin receptor in the prefrontal cortex, an area of the brain implicated in modulating social behaviors. However, treating the mice with a compound that blocks the receptor alleviated the behavioral problems and improved working memory.