Brain levels of FAAH, an enzyme that degrades a neurotransmitter that activates the cannabinoid 1 receptor, may contribute to the maintenance of excessive drinking and susceptibility to alcohol use disorder.
A variant of the FAAH gene increases vulnerability to THC in females and has a larger-scale impact on brain regions responsible for reward processing.
Fatty acid amide hydrolase (FAAH) inhibitors, a form of medication that boosts endocannabinoids, may be helpful in the treatment of PTSD. FAAH inhibition can improve the recall of fear extinction memories. The drugs could also help treat stress and other psychological disorders.
People with the specific genotype of the Cannabinoid receptor 1 gene may be more prone to cannabis use disorder. Researchers report those with FAAH rs324420 A continue to want more marijuana following use and are more drawn to cannabis-related imagery while under the influence of the drug.
A rare genetic mutation has been associated with pain insensitivity. The findings could further research into new treatments to target pain.
