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enteric nervous system

·August 11, 2023·6 min read

Rethinking the Gut’s Neurons: Newly Discovered Neurons Upend Established Theory

Previously, scientists believed that the enteric nervous system (ENS) development stopped before birth. However, recent findings overturn this by showing ENS development continues after birth in mice and humans.

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·June 6, 2023·4 min read

Progesterone’s Protective Role Against Parkinson’s in the Enteric Nervous System

Recent research illustrates a protective effect of progesterone on the enteric nervous system (ENS), often referred to as the body's "second brain". The study demonstrated that nerve cells treated with progesterone were more resistant to conditions simulating Parkinson's disease.

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·September 9, 2022·2 min read

Antibiotics Given in Infancy May Have Adverse Impact on Adult Gut Health

Early life exposure to antibiotics has a long-lasting effect on the enteric nervous system, microbiome, and gut function.

This shows a cross section of a mouse gut

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·October 20, 2021·3 min read

Glial Cells Crucial to Maintaining Healthy Gut Immunity

Glial cells coordinate immune responses in the gut following infection. Researchers report glial cells could be targets for therapeutics to treat inflammatory bowel disorders.

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·October 1, 2021·5 min read

Revealing the Logic of the Body’s Second Brain

Findings shed new light on the gut's enteric nervous system, offering hope for treatments for a range of disorders.

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·August 10, 2021·3 min read

New Insights Into How the ‘First Brain’ Works in the Gut

Study highlights how the enteric nervous system acts similarly to neural networks in the brain and spinal cord.

This shows a breakdown of the human body

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·December 7, 2020·4 min read

New Fundamental Knowledge of the ‘Abdominal Brain’

Neural mapping of the enteric nervous system reveals how fetal neurons form during development. The process of neural development in the ENT follows different principal to the development of neurons in the brain.

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·July 25, 2020·4 min read

Rely on Gut Feeling? How the Second Brain in Gut Communicates

Viscerofugal neurons inside the gut wall communicate to other neurons outside of the gut, near the spinal cord, to send messages to the brain.

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·February 18, 2020·5 min read

Parkinson’s biomarker may originate in gut

Using mouse models, researchers seeded alpha-synuclein aggregates in gut neurons and discovered the clumps can travel to neurons in the brain.

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·November 14, 2019·4 min read

Targeting alpha-synuclein in the gut may slow down Parkinson’s disease

Scientists are conducting experiments to see if targeting the enteric nervous system with a compound can inhibit the aggregation of alpha-synuclein and slow the progression of Parkinson's disease.

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·May 10, 2019·4 min read

Inflamed monkey guts produce Parkinson’s-related proteins

Inflammation of the colon is associated with alterations in alpha-synuclein expression and phosphorylation in the myenteric plexus of common marmoset monkeys. The findings support the growing body of evidence that inflammation may play a role in the development of Parkinson's disease.