In patients with cognitive decline, the cerebral spinal immune system is dramatically altered. The findings shed light on how inflammation and the immune system play a role in neurodegenerative diseases like Alzheimer's.
Artificially inducing peripheral inflammation in mice triggered the sudden onset of delirium-like cognitive dysfunction, and this was mediated by a disturbance in energy metabolism.
HIV can persist in the nervous system, even when the virus is suppressed. Even when the virus is suppressed, neurocognitive problems associated with the infection can persist.
Ceramide exposure impairs the ability for neurons to make energy by directly damaging mitochondria. Additionally, ceramides force neurons to rapidly uptake glucose in order to provide cellular energy.
A new study reports the atrophy of brain lesion volume predicts the development of more physical disabilities associated with multiple sclerosis.
According to researchers, Alzheimer's disease may be more prevalent in women, not simply because they live longer on average, but due to the APOE E4 gene. Researchers found the APOE association was greater for women in the Tau pathway than in men. However, there was no difference between APOE expression in the amyloid pathway in women compared to men.
A new study that used rhesus macaques with low levels of sociability revealed the animals had reduced levels of vasopressin in their cerebral spinal fluid, as did children diagnosed with ASD.
Researchers say their findings about immune system changes early in Alzheimer's could lead to new blood tests that may be used to detect the disease before it becomes symptomatic.
According to researchers, a small alcoholic drink each day may be beneficial for brain health. Using mice, researchers found low levels of alcohol consumption is associated with less brain inflammation and a more effective glymphatic system. This allows CSF to flow more efficiently through the brain and remove waste that can lead to neurodegenerative diseases.