Study identifies a short gene segment crucial for brain development and information processing. The absence of the gene segment induces altered social behaviors, learning difficulties, and memory deficits, which are hallmarks of a subset of ASD.
Study reveals how a protein that transports essential amino acids across the placenta plays a role in fetal development. Deficiencies of the SNAT4 protein may result in developmental abnormalities and a higher risk of miscarriage.
Using CRISPR gene editing, researchers introduce the SHANK3 gene variant into macaque monkeys. SHANK3 has previously been linked to autism in humans. The monkeys with the SHANK3 mutations exhibited behavioral traits and brain activity patterns similar to those seen in humans on the autism spectrum, Researchers hope the new model will facilitate new avenues of research for ASD.
The chemical probe CDr20 can label microglia in living cells, researchers report.
Using CRISPR-Cas9 gene editing, researchers identified actionable pathways responsible for the growth of glioblastoma stem cells. By reverse engineering brain cancer cells, multiple potential new targets for cancer treatments have been uncovered.
Researchers in China successfully used CRISPR gene editing to produce five monkey clones from the fibroblasts of a donor monkey with disease phenotypes.
Researchers re-purposed CRISPR gene editing technology to study genes targeted by particular antibiotics. The study sheds light on how pharmacologists can improve existing antibiotics and develop new ones.
Study reports a mutation in a single gene that causes hereditary frontotemporal dementia makes it harder for neurons to communicate, leading to neurodegeneration.
Using CRISPR techniques, researchers have uncovered a genetic network linked to autism.
The most common messenger RNA modification in mammals helps coordinate nerve cell response to memory inducting stimulus, a new study reveals.
With the aid of CRISPR gene editing techniques, researchers have identified a new biomarker for Alzheimer's disease. The study reports a deficiency of the protein STIM1 could be implicated in the sporadic version of the neurodegenerative disease.
Researchers use CRISPR gene editing technology to target GABA receptors in order to help treat mood disorders.
