Neuroimaging technology allowed researchers to capture the activity of microglia and astrocytes in the brain. The researchers were able to quantify alterations in the morphology of different cell populations implicated in neuroinflammation.
Mainly associated with COVID infection in the elderly, researchers report a young, otherwise healthy woman was diagnosed with COVID-19 CNS vasculitis following infection.
Post-mortem studies of COVID-19 patients revealed significant signs of neuroinflammation and impaired brain circuits which researchers believe were caused by the disease. Researchers said the changes noticed in the brains of COVID patients were similar to the changes that occur in both Alzheimer's and Parkinson's disease.
Neuroinflammation may be a key player in the pathological brain changes produced as a result of chronic opioid use. Microglia is likely responsible for the majority of the changes.
COVID-19 can spark a severe immune response in the central nervous system, affecting immune cells in the vascular system and brain.
MW189, a small molecule drug candidate, blocks abnormal inflammation in the brain which contributes to injury and disease induced neurological impairments.
Reducing the expression of the protein TOM1 in mouse models of Alzheimer's disease increased the pathology, exacerbated cognitive problems, and raised levels of inflammation in the brain. Restoring TOM1 reversed the effects. Findings suggest a new therapeutic target for treating dementia.
Hyaluronic acid, a substance naturally produced by the human body and a popular additive in cosmetics that boast plumper skin, may be a useful tool in treating neuroinflammation.
Capsular polysaccharide A (PSA), an envelope molecule, may help to boost the immune system and protect against potentially fatal neuroinflammation associated with Herpes Simplex Encephalitis (HSE). Mice given PSA survived exposure to a lethal herpes simplex viral infection, while those not treated with the probiotic did not, despite both groups being treated with a common antiviral used to treat HSE.
A new mouse study reveals long term exposure to bacteria associated with periodontal disease causes neuroinflammation and neurodegeneration, leading to similar effects of Alzheimer's disease. Researchers report periodontal disease may be an initiator of Alzheimer's.
Researchers have discovered a direct association between astrocytes and Alzheimer's disease. In a new study, researchers report astrocytes in the brains of Alzheimer's patients produced significantly more amyloid beta than astrocytes in the brains of people without the disease.
Researchers have identified increased inflammatory activation markers in the brains of people with major depressive disorder who report suicidal ideations. The findings support recent research that anti-inflammatories may provide antidepressant effects for some patients.