Proteins stand up to nerve cell regression
Study reveals the critical and novel roles Integrator complex proteins play in promoting healthy brain development in flies. ... Read More...
Brain Cancer
Scientists ‘reverse engineer’ brain cancer cells to find new targets for treatment
Using CRISPR-Cas9 gene editing, researchers identified actionable pathways responsible for the growth of glioblastoma stem cells. By reverse engineering brain cancer cells, multiple potential new targets for cancer treatments have been uncovered.... Read More...
Shutting down deadly pediatric brain cancer at its earliest moments
Dysregulation of Zfp36l1 causes neural lineage progenitor cells to grow rapidly, taking on the properties of fast growing stem cells as they become cancerous.... Read More...
New hope for treating childhood brain cancer
DIPG cancer cells exposed to MI-2 fail to maintain healthy levels of cholesterol and die quickly, by inhibiting lanosterol synthase. Additionally, while MI-2 destroys glioma cancer cells, the drug does not damage healthy brain cells.... Read More...
Depression, obesity, chronic pain could be treated by targeting the same key protein
Researchers have developed a compound that blocks the FKBP51 protein, which helps reduce chronic pain, provides positive outcomes for diet-induced obesity and improves symptoms of depression.... Read More...
New glioblastoma vaccine shows promising results in phase Ib clinical trial
A new vaccine for glioblastoma brain cancer suspends tumor growth and is well tolerated by patients, according to the results of an early phase clinical trial.... Read More...
New drug combination shows promise for common pediatric brain tumor
Combining carboplatin, a common chemotherapy drug, with everolimus, a drug that blocks mTOR, is effective at inducing apoptosis and slowing tumor growth in patients with pediatric low-grade glioma brain cancer.... Read More...
Radiation After Surgery Triples Survival for Ependymoma, a Type of Pediatric Brain Tumor
A study shows that postoperative radiation improves outcomes for children with ependymoma, even those with historically poor prognoses and the very young.... Read More...
Immunotherapy Can Be Effective in Treating People with Recurrent Glioblastoma
Researchers report administering immunotherapy treatment prior to surgery for those with recurring glioblastoma brain cancer is more effective that using the treatment after surgery.... Read More...
The Hitchhiker’s Guide to Defeating Glioblastoma
Researchers have developed a new approach that uses microRNA in combination with chemotherapy to help treat glioblastoma brain cancer. In preclinical models, the approach increases survival of the deadly brain cancer five fold.... Read More...
Targeted Treatment Shrinks Deadly Pediatric Brain Cancer Tumors
Researchers report a targeted therapy that blocks LSD1 effectively shrinks tumor size in mouse models of medulloblastoma, a form of pediatric brain cancer.... Read More...
Evaluating the Effects of Environmental Exposures on Neurological Disorders
Researchers have identified a number of environmental factors, including the herbicide Linuron, as inflammation activators in neurodegenerative disorders.... Read More...