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APOE-e4

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·July 10, 2019·3 min read

Impaired learning linked to family history of Alzheimer’s

People with a family history of Alzheimer's disease perform worse on learning tasks than those without a genetic link to the disease. The learning impairments appear to be exacerbated by the APOE E4 gene and diabetes.

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·June 24, 2019·2 min read

Alzheimer’s disease: Sex affects tau accumulation in the brain

Women with the ApoE e4 genetic risk factor for Alzheimer's are more susceptible to tau accumulation in the brain than men.

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·May 28, 2019·6 min read

High LDL cholesterol linked to early-onset Alzheimer’s

Elevated levels of LDL cholesterol has been linked to an increased risk of early-onset Alzheimer's disease, in those with and without a genetic risk factor. This suggests cholesterol could be an independent risk factor for dementia. Additionally, researchers identified a potential new genetic risk factor for early-onset Alzheimer's, a rare variant of the APOB gene.

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·April 7, 2019·5 min read

Does herpes cause Alzheimer’s?

The herpes simplex virus 1, the virus responsible for cold sores, may account for 50% of Alzheimer's disease cases. HSV1 causes protein deposits which are characteristic of Alzheimer's disease. Findings also reveal antiviral treatments can help to reduce the risk of developing Alzheimer's in those with HSV1.

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·August 24, 2018·5 min read

Testing Autobiographical Memory for Early Alzheimer’s Detection

Researchers report administering an autobiographical memory test to those with genetic risk factors for Alzheimer's may determine who will develop the disease. The study found those with the APOE e4 mutation describe autobiographical memories in much less detail than those without the mutation.

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·May 9, 2018·6 min read

Study Provides Robust Evidence of Sex Differences with Alzheimer’s Gene

According to researchers, Alzheimer's disease may be more prevalent in women, not simply because they live longer on average, but due to the APOE E4 gene. Researchers found the APOE association was greater for women in the Tau pathway than in men. However, there was no difference between APOE expression in the amyloid pathway in women compared to men.

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·February 27, 2018·4 min read

The Onset of Alzheimer’s:The Importance of Family History

Researchers report the closer a person gets to the age their parents started to develop Alzheimer's symptoms, the more likely they are to have amyloid plaques.

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·December 20, 2017·4 min read

A Non-Invasive Method to Detect Alzheimer’s

Researchers report an MRI test to measure smaller volumes in specific hippocampal regions could be used to detect Alzheimer's disease.

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·September 22, 2017·4 min read

Multi-Gene Test Predicts Alzheimer’s Better Than ApoE4 Alone

UCSF researchers have developed a new genetic risk factor test that takes into account more than 24 genetic variants, each of which are associated with a small risk of Alzheimer's disease. The researchers say the test is a better method to help identify preclinical Alzheimer's than testing for ApoE4 alone.

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·August 7, 2017·7 min read

Midlife Cardiovascular Risk Factors May Increase Chances of Dementia

Researchers report middle aged people expressing cardiovascular risk factors, including diabetes and high blood pressure, have an increased risk of developing dementia later in life.

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·February 3, 2017·4 min read

Poor Odor Identification May Be An Early Warning For Dementia

A new study supports olfactory testing as an early method to detect those at risk of developing dementia.

Image shows a a diagram of a mouse and the continental US.

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·January 31, 2017·7 min read

Air Pollution May Lead to Dementia in Older Women

Researchers report older women living in areas with fine particulate matter exceeding the EPA's standard are at significantly higher risk of developing dementia.