Latest

AMPK

Featured Neuroscience Visual Neuroscience

·July 21, 2025·6 min read

Youthful Blood Restores Aging Retina and Vision

Researchers demonstrated that systemic factors from young mice can rejuvenate the aging retina by alleviating cellular senescence and restoring function. Using heterochronic parabiosis and single-cell RNA sequencing, the study identified AdipoR1 and its downstream AMPK signaling as key drivers of retinal rejuvenation.

Featured Neuroscience

·April 5, 2023·3 min read

How to Prevent a High-Fat Diet From Throwing Metabolism Out of Whack

Eliminating SAPS3 from the genome of mice allowed the AMPK protein complex to activate and maintain normal energy balance, even with high-fat meals. This discovery could pave the way for developing a new approach to metabolic disorders such as obesity, diabetes, and fatty liver disease.

Electrophysiology Featured Neuroscience

·October 5, 2020·3 min read

How the Brain May Fuel Intense Neural Communication

The retrieval of mitochondria via a feedback loop is vital to sustaining synaptic transmission.

Featured Genetics

·August 14, 2020·7 min read

Loss of a Specific Enzyme Boosts Fat Metabolism and Exercise Endurance

The enzyme PHD3 plays a critical role in sensing nutrient availability and regulating the ability of muscles to break down fat. Blocking PHD3 production in mice leads to dramatic improvements in specific measures of fitness. Findings shed light on the key mechanism for how cells metabolize fuel and provide a novel understanding of muscle function and fitness.

Featured Neurology Neuroscience Open Neuroscience Articles

·February 11, 2020·6 min read

Human gut-in-a-dish model helps define ‘leaky gut,’ and outline a pathway to treatment

A new 3D human gut organoid reveals the molecular system that keeps the intestinal linings sealed and how dysfunction can occur. Findings reveal the diabetes drug metformin can help strengthen the intestinal lining.

This shows two people walking in the evening

Featured Neuroscience Open Neuroscience Articles

·April 18, 2019·6 min read

Two studies explore whether time of day can affect the body’s response to exercise

Two new studies report the time of day is a major modifier of exercise capacity, amplifying the impact exercise has on metabolic pathways and energy homeostasis. Evening exercise, researchers report, has the most productive effect.