Understanding the Link Between Hearing Loss and Dementia

Summary: Researchers propose an alternative mechanism to explain the link between hearing loss and dementia. The study sheds light on the role of the medial temporal lobe in auditory cognition.

Source: Newcastle University

Scientists have developed a new theory as to how hearing loss may cause dementia and believe that tackling this sensory impairment early may help to prevent the disease.

Hearing loss has been shown to be linked to dementia in epidemiological studies and may be responsible for a tenth of the 47 million cases worldwide.

Now, published in the journal Neuron, a team at Newcastle University, UK, provide a new theory to explain how a disorder of the ear can lead to Alzheimer’s disease – a concept never looked at before.

It is hoped that this new understanding may be a significant step towards advancing research into Alzheimer’s disease and how to prevent the illness for future generations.

Newcastle experts considered three key aspects; a common underlying cause for hearing loss and dementia; lack of sound-related input leading to brain shrinking; and cognitive impairment resulting in people having to engage more brain resources to compensate for hearing loss, which then become unavailable for other tasks.

The team propose a new angle which focuses on the memory centres deep in the temporal lobe. Their recent work indicates that this part of the brain, typically associated with long-term memory for places and events, is also involved in short-term storage and manipulation of auditory information.

They consider explanations for how changes in brain activity due to hearing loss might directly promote the presence of abnormal proteins that cause Alzheimer’s disease, therefore triggering the disease.

Professor Tim Griffiths, from Newcastle University’s Faculty of Medical Sciences, said: “The challenge has been to explain how a disorder of the ear can lead to a degenerative problem in the brain.

“We suggest a new theory based on how we use what is generally considered to be the memory system in the brain when we have difficulty listening in real-world environments.”

This shows a man getting a hearing test
It is hoped that this new understanding may be a significant step towards advancing research into Alzheimer’s disease and how to prevent the illness for future generations. Image is in the public domain.

Work on mechanisms for difficult listening is a central theme for the research group, including members in Newcastle, UCL and Iowa University, that has been supported by a Medical Research Council programme grant.

Dr Will Sedley, from Newcastle University’s Faculty of Medical Sciences, said: “This memory system engaged in difficult listening is the most common site for the onset of Alzheimer’s disease.

“We propose that altered activity in the memory system caused by hearing loss and the Alzheimer’s disease process trigger each other.”

“Researchers now need to examine this mechanism in models of the pathological process to test if this new theory is right.”

The experts developed the theory of this important link with hearing loss by bringing together findings from a variety of human studies and animal models. Future work will continue to look at this area.

About this dementia research article

Newcastle University
Helen Rae – Newcastle University
Image Source:
The image is in the public domain.

Original Research: Open access
“How can hearing loss cause dementia?” by TD Griffiths, M Lad, S Kumar, E Holmes, B McMurray, EA Maguire, AJ Billig, W Sedley. Neuron.


How can hearing loss cause dementia?

Epidemiological studies identify midlife hearing loss as an independent risk factor for dementia, estimated to account for 9% of cases. We evaluate candidate brain bases for this relationship. These bases include a common pathology affecting the ascending auditory pathway and multimodal cortex, depletion of cognitive reserve due to an impoverished listening environment, and the occupation of cognitive resources when listening in difficult conditions. We also put forward an alternate mechanism, drawing on new insights into the role of the medial temporal lobe in auditory cognition. In particular, we consider how aberrant activity in the service of auditory pattern analysis, working memory, and object processing may interact with dementia pathology in people with hearing loss. We highlight how the effect of hearing interventions on dementia depends on the specific mechanism and suggest avenues for work at the molecular, neuronal, and systems levels to pin this down.

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  1. Thanks for the informative update. My grandmother complains of hearing issues for the past one week. I was quite shocked to know about the relationship between hearing loss and dementia. This post is an eye-opener, and it made me realise the importance of using hearing aids.

  2. I lost my hearing in 1978. I was profoundly deaf and received my first Cochlear Implant in 1995. I had that one removes and a new system implanted in 2017. I am now 72. Have any studies been done on this topic of the effectiveness of the CI preventing dementia for people with hearing loss?

  3. I think some people with hearing loss develop Alzheimer’s disease because hearing people lack the incentives and skills to communicate with people who have hearing loss. Hearing people isolate those who are hard of hearing and deaf. The most common phrase we hear is: ” never mind”. So people with hearing loss get discouraged in communication settings and withdraw from others. That is the most basic element which should be included in any study. I have volunteered my time and taken care of people with Alzheimer’s disease and ALL of them had NO hearing loss. Explain that first.

  4. Ihave a family history of dementia and Alzheimers disease,Both my mum & my brother had hearing problems and have both died, my brother was 59, I am experiencing hearing lose aswell, which affects my daily living, I would like to be part of this study please, I would like to prevent this happening to me, and live longer. I am 51

  5. Very interesting. My husband (age 74years) has been diagnosed with onset dementia. He also can’t smell anything and has a hearing loss. Will it make a difference to the progression of the dementia if he gets a a hearing aid fitted now?

  6. My husbands mother went deaf then slowly died of dementia. My husband is 59 and lost his hearing in one ear 2019. Some days much worse then others. I want my husband to be part of research

  7. Is there any information regarding Multiple Sclerosis, hearing loss and dementia? Is there any info about Multiple Sclerosis on this site? The brain was mentioned so I was wondering before signing up. Thank you.

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